Technical Advances in AIDS Research in the Human Nervous System

  • Eugene O. Major
  • Jay A. Levy
  • Devera Schoenberg

Table of contents

  1. Front Matter
    Pages i-ix
  2. New Concepts in the Pathogenesis of HIV-1 Encephalopathy

    1. Front Matter
      Pages 1-1
    2. Joseph R. Berger, Richard Kaderman
      Pages 3-25
    3. John W. Griffin, Steven L. Wesselingh, Justin C. McArthur
      Pages 41-53
  3. Models of HIV-1 Infection and Neurotoxicity in the Human Fetal Nervous System

    1. Front Matter
      Pages 55-55
    2. Harris A. Gelbard, Kirk A. Dzenko, Leo Wang, Angela Talley, Harold James, Leon Epstein
      Pages 61-71
    3. Howard E. Gendelman, Peter Genis, Marti Jett, Hans S. L. M. Nottet
      Pages 73-88
    4. Eugene O. Major, Walter A. Atwood, Katherine E. Conant, Kei Amemiya, Judith Boston, Renee G. Traub
      Pages 89-103
    5. Avindra Nath, Meihui Ma
      Pages 117-122
  4. Model Cell Cultures from Adult Brain and Glioma Cell Lines

    1. Front Matter
      Pages 123-123
    2. Volker Erfle, Andrea Kleinschmidt, Markus Neumann, Alexandra Ludvigsen, Barbara K. Felber, George N. Pavlakis et al.
      Pages 125-133
    3. Kamel Khalili, J. Paul Taylor, Crystina Cupp, Michael Zeira, Shohreh Amini
      Pages 135-149
    4. Susan G. Wilt, Jia Min Zhou, Steve Wesselingh, Conrad V. Kufta, Monique Dubois-Dalcq
      Pages 151-162
  5. Neurotropism of HIV-1 Strains

    1. Front Matter
      Pages 175-175
    2. Ruth Brack-Werner, Thomas Görblich, Thomas Werner, Francesca Chiodi, Lutz Gürtler, Josef Eberle et al.
      Pages 189-204
    3. Ashlee V. Moses, Jay A. Nelson
      Pages 205-221
    4. Dale J. Benos, James K. Bubien, Beatrice H. Hahn, George M. Shaw, Etty N. Benveniste
      Pages 223-233
    5. Francisco González-Scarano, Jacques Fantini, David G. Cook, Neal Nathanson
      Pages 235-248
  6. Molecular Technology for the Detection and Analysis of HIV-1 in Nervous System Tissue

    1. Front Matter
      Pages 249-249
    2. Omar Bagasra, Thikkavarapu Seshamma, Joseph P. Pestaner, Roger J. Pomerantz
      Pages 251-266
    3. John J. Oprandy, Kei Amemiya, John H. Kenten, Richard G. Green, Eugene O. Major, Richard Massey
      Pages 281-297
  7. Development of New Techniques and Methods Applied to AIDS

    1. Front Matter
      Pages 299-299
    2. Peter Schmid, Andrew Conrad, Karl Syndulko, Elyse J. Singer, Ximing Li, Gongming Tao et al.
      Pages 301-316
    3. Melvyn P. Heyes, Eugene O. Major, Kuniaki Sato, Sanford M. Markey
      Pages 317-325
    4. Manfred Schubert, Akhil C. Banerjea, Soon-Young Paik, George G. Harmison, Chang-Jie Chen
      Pages 327-351
  8. Focus on AIDS and the Nervous System: Challenges During the Decade of the Brain

  9. Back Matter
    Pages 367-373

About this book


It is remarkable that each month the quantity ofarticles published on AIDS still that address numbers in the thousands. The basic, clinical and sociological aspects this epidemic have been vigorously investigated, and equally as extensively reported in traditional as well as new journals. Therefore, what can the reader ofthis volume expect to find that is different from the information already found in the literature? The authors of this text met in October 1993 to discuss not only AIDS and its effects on the nervous system but also to address the problem from the point of view of the diverse technologies that are used in understanding the disease. Just as the recog­ nition ofoncogenic viruses gave us insights into cellular genes that govern growth, the study ofHIV-I in the nervous system has opened new areas ofinvestigation in the nervous system. Use of human fetal and glioma-derived cell cultures, discovery of toxins in the nervous system, release and damage of cytokines in the brain, the neuropathic effects of HIV proteins, the investigation of new treatment for neuro­ AIDS, and virus detection strategies to identify latent HIVI infection are described in this volume. Basic and clinical investigators from more than thirty laboratories around the world contributed to the ideas discussed at the meeting, "Technical Advances in AIDS Research in the Human Nervous System.


AIDS HIV Nervous System Pathogene development infection tissue virus

Editors and affiliations

  • Eugene O. Major
    • 1
  • Jay A. Levy
    • 2
  • Devera Schoenberg
    • 1
  1. 1.National Institute of Neurological Disorders and StrokeBethesdaUSA
  2. 2.University of California, San FranciscoSan FranciscoUSA

Bibliographic information