Corona- and Related Viruses

1. Pathogenesis

   1. Neuronal Spread of Swine Hemagglutinating Encephalomyelitis Virus (HEV) 67N Strain in 4-Week-Old Rats

      • N. Hirano, R. Nomura, T. Tawara, K. Ono, Y. Iwasaki

      Pages 117-119

   2. Characterization of Human T Cell Clones Specific for Coronavirus 229E

      • J. S. Spencer, G. F. Cabirac, C. Best, L. McLaughlin, R. S. Murray

      Pages 121-129

   3. Studies on the in Vitro and in Vivo Host Range of Porcine Epidemic Diarrhoea Virus

      • Anna Utiger, Annekäthi Frei, Ana Carvajal, Mathias Ackermann

      Pages 131-133

   4. Coronaviruses in Polarized Epithelial Cells

      • J. W. A. Rossen, C. P. J. Bekker, W. F. Voorhout, M. C. Horzinek, A. Van Der Ende, G. J. A. M. Strous et al.

      Pages 135-138

   5. Isolation and Experimental Oral Transmission in Pigs of a Porcine Reproductive and Respiratory Syndrome Virus Isolate

      • R. Magar, Y. Robinson, C. Dubuc, R. Larochelle

      Pages 139-144

2. Immune Responses

   1. Front Matter

      Pages N2-N2

      PDF

   2. The Protective Role of Cytotoxic T Cells and Interferon against Coronavirus Invasion of the Brain

      • Ehud Lavi, Qian Wang

      Pages 145-149

   3. MHV-3 Induced Prothrombinase is Encoded by MUSFIBLP

      • Rebecca L. Parr, Laisum Fung, Jeffrey Reneker, Nancy Myers-Mason, Julian L. Leibowitz, Gary Levy

      Pages 151-157

   4. Demyelination Induced by Murine Coronavirus JHM Infection of Congenitally Immunodeficient Mice

      • J. J. Houtman, H. C. Hinze, J. O. Fleming

      Pages 159-163

   5. Induction of a Protective Immune Response to Murine Coronavirus with Non-Internal Image Anti-Idiotypic Antibodies

      • Mathilde Yu, Pierre J. Talbot

      Pages 165-172

   6. Transcription and Translation of Proinflammatory Cytokines Following JHMV Infection

      • Stephen A. Stohlman, Qin Yao, Cornelia C. Bergmann, Stanley M. Tahara, Shigeru Kyuwa, David R. Hinton

      Pages 173-178

   7. Pathology of MHV-A59 Infection in ß2 Microglobulin Negative Mice

      • Ehud Lavi, Qian Wang, James Gombold, Robyn Sutherland, Yvonne Paterson, Susan Weiss

      Pages 179-181

   8. Primary Murine Coronavirus Infection in Mice

      • S. Kyuwa, K. Machii, A. Okumura, Y. Toyoda

      Pages 183-184

   9. Neurovirulence for Rats of the JHMV Variants Escaped from Neutralization with the S1-Specific Monoclonal Antibodies

      • Fumihiro Taguchi, Hideka Suzuki, Hiromi Takahashi, Hideyuki Kubo

      Pages 185-187

   10. T Cell Immunodeficiency Involved in Pathogenicity of Attenuated MHV3 Mutants

       • L. Lamontagne, C. Page, J. P. Martin

       Pages 189-191

   11. Impairment of Bone Marrow Pre-B and B Cells in MHV3 Chronically-Infected Mice

       • P. Jolicoeur, L. Lamontagne

       Pages 193-195

3. Vaccine Development

   1. Front Matter

      Pages N3-N3

      PDF

   2. Development of Protection against Coronavirus Induced Diseases

      • Luis Enjuanes, Cristian Smerdou, Joaquín Castilla, Inés M. Antón, Juan M. Torres, Isabel Sola et al.

      Pages 197-211

   3. Production and Immunogenicity of Multiple Antigenic Peptide (MAP) Constructs Derived from the S1 Glycoprotein of Infectious Bronchitis Virus (IBV)

      • Mark W. Jackwood, Deborah A. Hilt

      Pages 213-219

   4. Protection of Cats from Infectious Peritonitis by Vaccination with a Recombinant Raccoon Poxvirus Expressing the Nucleocapsid Gene of Feline Infectious Peritonitis Virus

      • T. L. Wasmoen, N. P. Kadakia, R. C. Unfer, B. L. Fickbohm, C. P. Cook, H-J. Chu et al.

      Pages 221-228

Corona- and related viruses are important human and animal pathogens that also serve as models for other viral-mediated diseases. Interest in these pathogens has grown tremendously since the First International Symposium was held at the Institute of Virology and Immunobiology of the University of Wiirzburg, Germany. The Sixth International Symposium was held in Quebec City from August 27 to September I, 1994, and provided further understanding of the molecular biology, immunology, and pathogenesis of corona-, toro-, and arterivirus infections. Lectures were given on the molecular biology, pathogenesis, immune responses, and development of vaccines. Studies on the pathogenesis of coronavirus infections have been focused mainly on murine coronavirus, and mouse hepatitis virus. Neurotropic strains ofMHV (e.g., JHM, A59) cause a demyelinating disease that has served as an animal model for human multiple sclerosis. Dr. Samuel Dales, of the University of Western Ontario, London, Canada, gavea state-of-the-art lecture on our current under­ standing of the pathogenesis of JHM-induced disease.

• Antigen
• Pathogene
• development
• immunobiology
• infections
• nervous system
• protein
• virus

• Armand-Frappier Institute, University of Québec, Laval, Canada

  Pierre J. Talbot

• The Toronto Hospital, University of Toronto, Toronto, Canada

  Gary A. Levy

Policies and ethics