© 2001


Its Molecular Biology and Role in Human Health

  • Dolph L. Hatfield

Table of contents

  1. Front Matter
    Pages i-xix
  2. Introduction

    1. Dolph L. Hatfield
      Pages 1-4
  3. Biosynthesis of selenocysteine and its incorporation into protein

    1. Front Matter
      Pages 5-5
    2. August Böck
      Pages 7-22
    3. Bradley A. Carlson, F. Javier Martin-Romero, Easwari Kumaraswamy, Mohamed E. Moustafa, Huijun Zhi, Dolph L. Hatfield et al.
      Pages 23-32
    4. Glover W. Martin III, Marla J. Berry
      Pages 45-53
    5. Paul R. Copeland, Donna M. Driscoll
      Pages 55-67
    6. John B. Mansell, Marla J. Berry
      Pages 69-80
    7. Roger A. Sunde
      Pages 81-96
  4. Selenium-containing proteins

    1. Front Matter
      Pages 97-97
    2. Thressa C. Stadtman
      Pages 115-122
    3. Kristina E. Hill, Raymond F. Burk
      Pages 123-135
    4. L. Walt Ream, William R. Vorachek, Philip D. Whanger
      Pages 137-146
    5. Vadim N. Gladyshev, Alan M. Diamond, Dolph L. Hatfield
      Pages 147-155
    6. Leopold Flohé, Regina Brigelius-Flohé
      Pages 157-178
    7. Arne Holmgren
      Pages 179-188
    8. Donald L. St. Germain
      Pages 189-202
  5. Selenium and human health

    1. Front Matter
      Pages 203-203

About this book


As discussed in this book, a large body of evidence indicates that selenium is a cancer chemopreventive agent. Further evidence points to a role of this element in reducing viral expression, in preventing heart disease, and other cardiovascular and muscle disorders, and in delaying the progression of AIDS in HIV infected patients. Selenium may also have a role in mammalian development, in male fertility, in immune function and in slowing the aging process. The mechanism by which selenium exerts its beneficial effects on health may be through selenium-containing proteins. Selenium is incorporated into protein as the amino acid selenocysteine. Selenocysteine utilizes a specific tRNA, a specific elongation factor, a specific set of signals, and the codeword, UGA, for its cotranslational insertion into protein. It is indeed the 21st naturally occurring amino acid to be incorporated into protein and marks the first and only expansion of the genetic code since the code was deciphered in the mid 1960s.


Amino acid Mammalia aging cancer development metabolism proteins translation

Editors and affiliations

  • Dolph L. Hatfield
    • 1
  1. 1.National Cancer InstituteUSA

Bibliographic information