Evolving Concepts in Sepsis and Septic Shock

  • Peter Q. Eichacker
  • Jérôme Pugin

Part of the Perspectives on Critical Care Infectious Diseases book series (CCID, volume 2)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Javier Pérez, R. Phillip Dellinger
    Pages 1-15
  3. Jean-Louis Vincent
    Pages 17-25
  4. Jérôme Pugin
    Pages 27-44
  5. Christian Martin, Thierry Roger, Thierry Calandra
    Pages 45-67
  6. Bradley D. Freeman, Barbara A. Zehnbauer
    Pages 69-79
  7. Sergey Goodman, Charles L. Sprung
    Pages 97-109
  8. Jonathan Sevransky, Charles Natanson
    Pages 129-143
  9. Jean-François Dhainaut, Nathalie Marin, Alain Cariou
    Pages 145-161
  10. Hans-Dieter Volk, Kerstin Wolk, Robert Sabat, Wolf-Dietrich Döcke, Petra Reinke
    Pages 163-174
  11. Back Matter
    Pages 189-195

About this book


Much research over the past 30 to 40 years has shown that the inflammatory response, while critical for host defense during microbial infection, may itself play a central role in the pathogenesis of sepsis. Although key mediators responsible for this injury have been identified, efforts clinically to augment our conventional antimicrobial and supportive therapies during sepsis with agents modulating the inflammatory response have been unsuccessful. As a result, the mortality associated with this lethal syndrome, especially when complicated by shock, has remained persistently high. Unfortunately, during this same period of time, the incidence of sepsis has accelerated as other fields of medicine have relied increasingly on therapies that predispose to infection.
While frustrating, overall this experience in the field of sepsis has not been without value. Most importantly, it has helped define on several different levels the complexity of the septic patient. Recognizing and addressing this complexity as discussed by each of the contributors to Evolving Concepts in Sepsis and Septic Shock may now provide new inroads into the treatment of sepsis.


Atmen Sepsis antimicrobial bacteria infection infections

Editors and affiliations

  • Peter Q. Eichacker
    • 1
  • Jérôme Pugin
    • 2
  1. 1.Critical Care Medicine DepartmentWarren Grant Magnuson Clinical Center National Institutes of HealthBethesdaUSA
  2. 2.Division of Medical Intensive CareUniversity Hospital of GenevaGeneva 14Switzerland

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers 2001
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-5625-7
  • Online ISBN 978-1-4615-1581-4
  • Series Print ISSN 1568-2501
  • Buy this book on publisher's site