© 2001

Potassium Channels in Cardiovascular Biology

  • Stephen L. Archer
  • Nancy J. Rusch

Table of contents

  1. Front Matter
    Pages i-xlv
  2. Molecular Biology of Potassium Channels

    1. Front Matter
      Pages 1-1
    2. Warren J. Gallin, Andrew N. Spencer
      Pages 3-16
    3. Pratap Meera, Martin Wallner, Ligia Toro
      Pages 49-70
    4. S. L. Shyng, A. N. Lopatin, C. G. Nichols
      Pages 71-88
  3. Potassium Channel Expression and Function

    1. Front Matter
      Pages 89-89
    2. Robert O. Koch, Maria Trieb, Alexandra Koschak, Siegmund G. Wanner, Kathryn M. Gauthier, Nancy J. Rusch et al.
      Pages 91-102
    3. Michael J. Morales, Mulugu V. Brahmajothi, Donald L. Campbell, Harold C. Strauss
      Pages 103-118
    4. James S. Trimmer, Kenneth J. Rhodes
      Pages 163-175
  4. Pharmacology of Potassium Channels

    1. Front Matter
      Pages 193-193
    2. Brian Robertson
      Pages 195-217
    3. Maria L. Garcia, Gregory J. Kaczorowski
      Pages 219-234
    4. Eric Blanc, Hervé Darbon
      Pages 235-256
    5. Andre Terzic, Michel Vivaudou
      Pages 257-277
  5. Potassium Channels in the Heart

    1. Front Matter
      Pages 279-279

About this book


Potassium channels (K+) are membrane-spanning proteins which serve many important functions and are becoming a hot topic in physiology. K+ channels determine or modulate many functions of vascular smooth muscle, endothelial and inflammatory cells, and thus are central to regulation of arterial tone and control of cell proliferation. They are also promising targets for antihypertensive treatments with drugs which open and close specific types of K+ channels, making for an active field of research. With their ability to control vascular tone, voltage-gated K+ channels play a significant role in both pulmonary and systemic hypertension as well as in cardiac arrhythmias. This book will highlight the latest discoveries by leading researchers pertaining to the role of K+ channels in the heart and blood vessels in normal physiology and a variety of disease states.


blood vessel cardiovascular cells endothelium hypertension physiology proteins smooth muscle

Editors and affiliations

  • Stephen L. Archer
    • 1
  • Nancy J. Rusch
    • 2
  1. 1.Walter McKenzie Health Science CentreUniversity of Alberta HospitalEdmontonCanada
  2. 2.Medical College of WisconsinMilwaukeeUSA

Bibliographic information