Oxygen/Nitrogen Radicals: Cell Injury and Disease

1. Effect of inhaled crystalline silica in a rat model: Time course of pulmonary reactions

   • Vincent Castranova, Dale Porter, Lyndell Millecchia, Jane Y. C. Ma, Ann F. Hubbs, Alexander Teass

   Pages 177-184

2. The role of AP-1, NF-кB and ROS/ NOS in skin carcinogenesis: The JB6 model is predictive

   • Arindam Dhar, Mathew R. Young, Nancy H. Colburn

   Pages 185-193

3. Reactive oxygen species in choline deficiency induced carcinogenesis and nitrone inhibition

   • Robert A. Floyd, Yashige Kotake, Kenneth Hensley, Dai Nakae, Yoichi Konishi

   Pages 195-203

4. Tumor necrosis factor-α gene promoter polymorphism in coal workers’ pneumoconiosis

   • Kyoung Ah Kim, Yong-Yeun Cho, Jung Sik Cho, Ki Hwa Yang, Woon Kyu Lee, Kweon-Haeng Lee et al.

   Pages 205-209

5. Nitric oxide decreases the sensitivity of pulmonary endothelial cells to LPS-induced apoptosis in a zinc-dependent fashion

   • Zi-Lue Tang, Karla J. Wasserloos, XiangHong Liu, Molly S. Stitt, Ian J. Reyolds, Bruce R. Pitt et al.

   Pages 211-217

6. Cytokine polymorphisms in silicosis and other pneumoconiosis

   • Berran Yucesoy, Val vallyathan, Douglas P. Landsittel, Petia Simeonova, Michael I. Luster

   Pages 219-224

7. Endogenous regulation of the acute inflammatory response

   • Peter A. Ward, Alex B. Lentsch

   Pages 225-228

8. Role of nitric oxide in liver ischemia and reperfusion injury

   • Ian N. Hines, Shigeyuki Kawachi, Shigeyuki Harada, Kevin P. Pavlick, Jason M. Hoffman, Sulaiman Bharwani et al.

   Pages 229-237

9. Oxidative stress and TNF-a induce histone Acetylation and NF-кB/AP-1 activation in Alveolar epithelial cells: Potential mechanism In gene transcription in lung inflammation

   • Irfan Rahman, Peter S. Gilmour, Luis Albert Jimenez, William MacNee

   Pages 239-248

10. Heme oxygenase/carbon monoxide signaling path-ways: Regulation and functional significance

    • Stefan W. Ryter, Leo E. Otterbein, Danielle Morse, Augustine M. K. Choi

    Pages 249-263

11. The Role of Oxidative Stress in Nickel and Chromate Genotoxicity

    • Max Costa, Konstantin Salnikow, Jessica E. Sutherland, Limor Broday, Wu Peng, Qunwei Zhang et al.

    Pages 265-275

12. Arsenic carcinogenicity: Relevance of c-Src activation

    • Petia P. Simeonova, Michael I. Luster

    Pages 277-282

13. Roles of ferritin and iron in ischemic preconditioning of the heart

    • Eduard Berenshtein, Boris Vaisman, Chaya Goldberg-Langerman, Nahum Kitrossky, Abraham M. Konijn, Mordechai Chevion

    Pages 283-292

14. Molecular mechanisms of Cr(VI)-induced carcinogenesis

    • Min Ding, Xianglin Shi

    Pages 293-300

15. Arsenic induces oxidative DNA damage in mammalian cells

    • Maris Kessel, Su Xian Liu, An Xu, Regina Santella, Tom K. Heil

    Pages 301-308

16. Generation of reactive oxygen species in the enzymatic reduction of PbCrO4and related DNA damage

    • Stephen S. Leonard, Val Vallyathan, Vince Castranova, Xianglin Shi

    Pages 309-315

17. Soluble metals as well as the insoluble particle fraction are involved in cellular DNA damage induced by particulate matter

    • Ad M. Knaapen, Tingming Shi, Paul J.A. Borm, Roel P.F. Schins

    Pages 317-326

18. Nitroxides as antioxidants: Tempol protects against E09 cytotoxicity

    • Ayelet M. Samuni, William DeGraff, Murali C. Krishna, James B. Mitchell

    Pages 327-333

19. Reversal of fluoride induced cell injury through elimination of fluoride and consumption of diet rich in essential nutrients and antioxidants

    • A. K. Susheela, Madhu Bhatnagar

    Pages 335-340

20. Measurements in vivo of parameters pertinent to ROS/RNS using EPR spectroscopy

    • Nadeem Khan, Harold Swartz

    Pages 341-357

A veritable mountain of literature has been published showing the causal relationship of reactive oxygen/nitrogen species in human disease conditions, and there has been an explosion in the understanding of oxidative stress, the protective role of antioxidants and molecular events involved in the regulation of transcription, editing, and translation of key events leading to disease processes. Strategies need to be developed for prevention of diseases by allowing scientists and clinicians to obtain information on new and emerging advances. The molecular mechanisms involved in several diseases including Alzheimer's disease, atherosclerosis, diabetes, arthritis, and Parkinson's disease, as well as disorders of the eye, skin, cardiac, and pulmonary systems are discussed in this volume, along with scientific evidence supporting the value of dietary supplementation with antioxidants in the prevention of cellular damage leading to chronic disease. Special in vivo techniques are also discussed at length, along with the role of molecular studies in human risk assessment.

• Activation
• Alveolar macrophages
• DNA
• Drogen
• Immunity
• Macrophages
• Nucleotide
• Oxidation
• gene expression
• hydrogen peroxide
• molecular mechanisms
• proteins
• regulation
• transcription
• translation

• Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, USA

  Val Vallyathan, Xianglin Shi, Vince Castranova

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