Overview
- Editors:
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Nader G. Abraham
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New York Medical College, Valhalla, USA
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Table of contents (43 chapters)
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Clinical Implications of Heme Oxygenase System in Inflammation
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- Camille Taillé, Roberta Foresti, Colin Green, Michel Aubier, Roberto Motterlini, Jorge Boczkowski
Pages 205-213
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- P. O. Berberat, L. Günther, S. Brouard, M. P. Soares, F. H. Bach
Pages 215-226
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- Mark A. Perrella, Shaw-Fang Yet
Pages 227-237
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Heme Oxygenase and Cardiovascular System
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Front Matter
Pages 239-239
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- Siobhan T. Pittock, Karl A. Nath
Pages 241-250
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- Prasun K. Datta, Elias A. Lianos
Pages 251-258
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- Tobias Polte, Anke Hemmerle, Nina Grosser, Aida Abate, Henning Schröder
Pages 259-268
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- Jesus Araujo, Kazunobu Ishikawa, Aldons J. Lusis
Pages 269-278
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- Germán Camejo, Ana Z. Fernandez, Flor López, Alfonso Tablante, Egidio Romano, Eva Hurt-Camejo et al.
Pages 279-292
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- Amel F. Khelifi, Vivien E. Prise, Roberta Foresti, James E. Clark, Chryso Kanthou, Roberto Motterlini et al.
Pages 303-312
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- David Sacerdoti, Angelo Gatta
Pages 313-322
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Heme Oxygenase System and Oxidative Stress Response
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Front Matter
Pages 323-323
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- A. Yachie, T. Toma, S. Shimura, L. Yue, K. Morimoto, K. Maruhashi et al.
Pages 325-334
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- Maria Alfonsina Desiderio, Lorenza Tacchini
Pages 335-341
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- Maivel H. Ghattas, Linus T. Chuang, Nader G. Abraham
Pages 343-351
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- Gerben J. Schaaf, Roel F. M. Maas, Els M. de Groene, Johanna Fink-Gremmels
Pages 353-363
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- Stephan Immenschuh, Thomas Kietzmann
Pages 365-375
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- Daniel Stewart, Julia L. Cook, Jawed Alam
Pages 377-386
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- Toru Takahashi, Reiko Akagi, Hiroko Shimizu, Masahisa Hirakawa, Shigeru Sassa
Pages 387-397
About this book
Heme oxygenase is rapidly taking its place as the centerpiece of multiple inter acting metabolic systems. Only 25 years ago heme oxygenase and its metabolic prod ucts appeared to be merely a simple metabolic system-one substrate, heme; one enzyme, heme oxygenase; and one set of products, iron to be recycled, and bilirubin and carbon monoxide to be disposed. From a group of about 25 people in 1974, as judged by attendance at various Gordon conferences, heme oxygenase has, in the year 2000, attracted working scientists-and clinicians I might add-by the hundreds and has produced referenced publications by the thousands. It is well-deserved attention. Heme oxygenase system is now similar to the metabolic networks surrounding glucose in those complex maps of glycolytic and non-glycolytic metabolic pathways, which we had to memorize as students. The relevance of heme oxygenase to regulatory biology was recognized many years ago, but the work conducted over the past five years has created a new wave of emphasis focusing on genetic manipulation to alter heme oxygenase gene expression, the regulatory actions of heme oxygenase products including carbon monoxide, and the significance of changes in the heme oxygenase system. The physiological and pathological relevance of heme oxygenase in the brain, heart, liver, bone marrow, organ transplant, lung and kidney, opens many areas of investigation in various dis ciplines. Advances in the pharmacology of bilirubin and its ability as an antioxidant have provided a new avenue in clinical research.
Editors and Affiliations
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New York Medical College, Valhalla, USA
Nader G. Abraham