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PAS Proteins: Regulators and Sensors of Development and Physiology

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xiii
  2. Structure of the PAS Fold and Signal Transduction Mechanisms

    • Zhong Xuejun, Hao Bing, Michael K. Chan
    Pages 1-16
  3. Signal Transduction in Prokaryotic PAS Domains

    • Barry L. Taylor, Mark S. Johnson, Kylie J. Watts
    Pages 17-50
  4. bHLH-PAS Proteins in C. Elegans

    • Jo Anne Powell-Coffman
    Pages 51-68
  5. The AH Receptor

    • Yao Guang, Eric B. Harstad, Christopher A. Bradfield
    Pages 149-182
  6. PAS Proteins in the Mammalian Circadian Clock

    • John B. Hogenesch, Steve A. Kay
    Pages 231-252
  7. Back Matter

    Pages 253-263

About this book

PAS proteins control numerous physiological and developmental events, and span phylogeny from bacteria to man. Bacterial and plant PAS proteins act as sensors of environmental stimuli, including light, oxygen, and energy status.

Not surprising, given these roles, there is intense investigation of the roles of bHLH-PAS proteins in issues of human health including: (1) cancer induction, (2) cancer growth and vascularity, (3) birth defects, including Down syndrome, (4) appetite control and obesity, (5) sleep rhythm disorders, and (6) mental health disorders such as social interactions and learning.

PAS proteins encompass many fields of biology, and scientists who work in these fields (circadian rhythms, oxygen regulation, toxin metabolism, bacterial sensors, and development) are an audience, particularly those who actively work on PAS proteins and researchers interested in transcriptional control, signal transduction, and evolution.

Editors and Affiliations

  • The University of North Carolina at Chapel Hill, Chapel Hill, USA

    Stephen T. Crews

Bibliographic Information

  • Book Title: PAS Proteins: Regulators and Sensors of Development and Physiology

  • Editors: Stephen T. Crews

  • DOI: https://doi.org/10.1007/978-1-4615-0515-0

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Kluwer Academic Publishers 2003

  • Hardcover ISBN: 978-1-4020-7586-5Published: 30 September 2003

  • Softcover ISBN: 978-1-4613-5115-3Published: 21 October 2012

  • eBook ISBN: 978-1-4615-0515-0Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIII, 263

  • Topics: Protein Science, Biochemistry, general, Human Genetics, Medical Microbiology, Neurosciences, Oncology

Buy it now

Buying options

Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access