Myocardial Ischemia and Preconditioning

  • Naranjan S. Dhalla
  • Nobuakira Takeda
  • Manjeet Singh
  • Anton Lukas

Part of the Progress in Experimental Cardiology book series (PREC, volume 6)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Ischemia/Reperfusion Injury: Basic Mechanisms

    1. Front Matter
      Pages 1-1
    2. Gianmario Sambuceti, Mario Marzilli, Andrea Mari, Cecilia Marini, Mathis Schluter, Paolo Marzullo et al.
      Pages 3-12
    3. Satoshi Takeo, Takeshi Iwai, Kouichi Tanonaka
      Pages 35-60
    4. Shiro Hoshida, Nobushige Yamashita, Kinya Otsu, Masatsugu Hori
      Pages 61-70
    5. Alicia Mattiazzi, Cecilia Mundiña-Weilenmann, Leticia Vittone, Matilde Said, Paola Ferrero
      Pages 71-81
    6. Paramjit S. Tappia, Girma Asemu, Naranjan S. Dhalla
      Pages 83-93
    7. Thomas Podzuweit, Markus Schmook, Klaus Binz, Sylvia Thomas
      Pages 95-125
    8. Ján Slezák, Jan Styk, Olga Slezakova, Gerd Wallukat, Peter Karczewski, Wolfgang Schulze et al.
      Pages 127-138
    9. Elizabeth Röth, Gábor Jancsó, Gyula Temes, János Lantos
      Pages 139-148
    10. Rana M. Temsah, Thomas Netticadan, Naranjan S. Dhalla
      Pages 149-164
  3. Mechanisms Underlying Ischemic Preconditioning-Induced Cardioprotection

    1. Front Matter
      Pages 179-179
    2. Yigang Wang, Meifeng Xu, Mitsuhiro Kudo, Ahmar Ayub, Muhammad Ashraf
      Pages 189-204
    3. Meifeng Xu, Yigang Wang, Ahmar Ayub, Muhammad Ashraf
      Pages 205-218
    4. Marie-Claire Toufektsian, Stéphane Tanguy, Sandrine Morel, Nada Benajiba, François Boucher, Joël de Leiris
      Pages 219-233
    5. Suresh Kumar Gupta, Meenu Sharma, Ipseeta Mohanty, Dharamvir S. Arya
      Pages 235-248

About this book


Current evidence suggests that the ischemic preconditioning response is a multi-factorial process consisting of an initial early trigger, an intermediate mediator, and an end effector. Each of these steps in is now its own intense area of investigation. The need to render the heart ischemic for a brief period to invoke the preconditioning response is currently the major factor limiting clinical application of this powerful cardioprotective strategy. Recent research efforts have utilized brief exposures to pharmacological agents, in lieu of a brief preconditioning ischemia, to trigger/mimic the ischemic preconditioning-induced response. The World Heart Congress held in Winnipeg in July 2001 provided a forum for the presentation of new insights into the basic mechanisms of ischemia and reperfusion injury, as well as novel strategies to protect the heart from cell death, ventricular arrhythmias, and contractile dysfunction. Many pioneers in the fields of ischemia-reperfusion injury and preconditioning-induced protection presented there and the chapters in this book represent selected papers from these symposia.


PTCA arrhythmia drugs heart heart disease

Editors and affiliations

  • Naranjan S. Dhalla
    • 1
  • Nobuakira Takeda
    • 2
  • Manjeet Singh
    • 3
  • Anton Lukas
    • 1
  1. 1.Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of MedicineUniversity of ManitobaWinnipegCanada
  2. 2.Aoto Hospital, Department of Internal MedicineJikei University School of MedicineTokyoJapan
  3. 3.Dept. of Pharmaceutical Sciences & Drug ResearchPunjabi UniversityPatialaIndia

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers 2003
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-5036-1
  • Online ISBN 978-1-4615-0355-2
  • Series Print ISSN 1389-1774
  • About this book