Signal Transduction and Cardiac Hypertrophy

  • Naranjan S. Dhalla
  • Larry V. Hryshko
  • Elissavet Kardami
  • Pawan K. Singal

Part of the Progress in Experimental Cardiology book series (PREC, volume 7)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Cardiac Adaptation and Remodeling

    1. Front Matter
      Pages 1-1
    2. Florian Grabellus, Bodo Levkau, Hans-H. Scheld, Atsushi Takeda, Michael Erren, Jörg Stypmann et al.
      Pages 3-18
    3. Horacio E. Cingolani, Néstor G. Perez, María C. Camilión de Hurtado
      Pages 37-48
    4. Emanuele Giordano, Lisa M. Shantz, Rebecca A. Hillary, Carlo Guarnieri, Claudio M. Caldarera, Anthony E. Pegg
      Pages 49-56
    5. Hideaki Kawaguchi, Noriteru Morita, Takeshi Murakami, Kenji Iizuka
      Pages 57-67
    6. František Kolář, Ivana Ošt’ádalová, Bohuslav Ošt’ádal, Jan Neckář, Ondrej Szárszoi
      Pages 69-83
    7. Hiroyuki Takano, Yunzeng Zou, Hiroshi Akazawa, Toshio Nagai, Miho Mizukami, Haruhiro Toko et al.
      Pages 85-94
    8. Barbara Knoblach, Kimitoshi Nakamura, Murray Robertson, Marek Michalak
      Pages 95-103
    9. María C. Camilión de Hurtado, Néstor G. Pérez, Irene L. Ennis, Bernardo V. Alvarez, Horacio E. Cingolani
      Pages 125-135
  3. Cardiac Signal Transduction

    1. Front Matter
      Pages 137-137
    2. Ernesto Alejandro Aiello
      Pages 139-147
    3. Ranjinder S. Sidhu, Richard R. Clough, Rajinder P. Bhullar
      Pages 167-179
    4. Robert Denyer, Sandhya Sanghi, Rajesh Kumar, David E. Dostal
      Pages 181-198
    5. Claudio Stefanelli, Carla Pignatti, Benedetta Tantini, Emanuele D. Giordano Francesca Bonavita, Maddalena Zini, Flavio Flamigni et al.
      Pages 199-206
    6. Kenichi Hongo, Yoichiro Kusakari, Makoto Kawai, Masato Konishi, Seibu Mochizuki, Satoshi Kurihara
      Pages 237-247
    7. Michael P. Czubryt, Grant N. Pierce
      Pages 249-263
    8. Valdur Saks, Florence Appaix, Yves Usson, Karen Guerrero, Jose Olivares, Enn Seppet et al.
      Pages 265-284
    9. Lakshmikuttyamma Ashakumary, Rakesh Kakkar, Ponniah Selvakumar, Mohammed Khysar Pasha, Rajendra K. Sharma
      Pages 285-302
    10. Christoph Maack, Michael Böhm
      Pages 303-321
    11. Paramjit S. Tappia, Nina Aroutiounova, Naranjan S. Dhalla
      Pages 335-347
    12. M. A. Q. Siddiqui, Eduardo Mascareno
      Pages 349-356
  4. Genetic Approaches to Investigative Cardiac Signal Transduction

    1. Front Matter
      Pages 357-357
    2. Benedetta Tantini, Carla Pignatti, Flavio Flamigni, Claudio Stefanelli, Monia Fattori, Annalisa Facchini et al.
      Pages 359-371
    3. Karen A. Detillieux, Sarah K. Jimenez, David P. Sontag, Elissavet Kardami, Peter W. Nickerson, Peter A. Cattini
      Pages 373-391
    4. Ronald L. Mellgren, Tao Lu, Ying Xu
      Pages 403-415
    5. Ryozo Nagai, Takayuki Shindo, Ichiro Manabe, Toru Suzuki, Kennichi Aizawa, Saku Miyamoto et al.
      Pages 417-423
    6. Toshiyuki Takahashi, Yasuyuki Sugishita, Tatsuya Shimizu, Atsushi Yao, Kazumasa Harada, Ryozo Nagai
      Pages 439-447
    7. Angel Zarain-Herzberg, Georgina Alvarez-Fernández
      Pages 479-496
  5. Back Matter
    Pages 497-508

About this book


Cellular signaling in cardiac muscle refers to the myriad of stimuli and responses that direct and control the physiological operation of this organ. Our understand­ ing of these complex signaling cascades has increased dramatically over the past few decades with the advent of molecular tools for their dissection. Moreover, this infor­ mation is beginning to provide tangible targets towards manipulating cardiac func­ tion in the setting of cardiovascular disease. The mechanisms and factors that regulate cardiac cell growth are of particular interest as both adaptive and maladaptive responses can occur during cardiac hypertrophy. Cardiac hypertrophy describes the increase in individual cardiac myocyte size that is accomplished through the series and/or parallel addition of sarcomeres. The ability of cardiac muscle to increase in size through hyperplasia becomes highly restricted or negligible shortly after birth. Consequently, the increase in heart size associated with development and growth of an individual occurs through hypertrophy. In response to a chronic increase in workload, cardiac muscle cells can dramatically increase in size to face their increasing contractile demands. While this plasticity is clearly a ben­ eficial response under many conditions, it can be highly deleterious and inappropri­ ate under others. For example, cardiac hypertrophy associated with endurance exercise clearly enhances athletic performance. In contrast, the hypertrophy associated with chronic hypertension, stenotic or regurgitant heart valves, or following a myocardial infarction often continues far beyond the period where this adaptive response is ben­ eficial.


heart heart failure myocardial infarction

Editors and affiliations

  • Naranjan S. Dhalla
    • 1
  • Larry V. Hryshko
    • 1
  • Elissavet Kardami
    • 1
  • Pawan K. Singal
    • 1
  1. 1.Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre Faculty of MedicineUniversity of ManitobaWinnipegCanada

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers 2003
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-5032-3
  • Online ISBN 978-1-4615-0347-7
  • Series Print ISSN 1389-1774
  • Buy this book on publisher's site