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Cyclic ADP-Ribose and NAADP

Structures, Metabolism and Functions

  • Hon Cheung Lee

Table of contents

  1. Front Matter
    Pages I-XVIII
  2. Hon Cheung Lee
    Pages 1-21
  3. Hon Cheung Lee, Cyrus B. Munshi, Richard Graeff
    Pages 23-43
  4. Antony Galione
    Pages 45-64
  5. Enza Ferrero, Fabio Malavasi
    Pages 65-79
  6. Richard Graeff, Hon Cheung Lee
    Pages 101-120
  7. Timothy F. Walseth, Hon Cheung Lee
    Pages 121-142
  8. Hon Cheung Lee
    Pages 143-166
  9. Anthony J. Morgan, Antony Galione
    Pages 167-197
  10. Grant C. Churchill, Sandip Patel, Justyn M. Thomas, Antony Galione
    Pages 199-215
  11. Frances E. Lund, Troy D. Randall, Santiago Partida-Sánchez
    Pages 217-240
  12. Antonio De Flora, Lucrezia Guida, Luisa Franco, Santina Bruzzone, Elena Zocchi
    Pages 241-267
  13. Shin Takasawa, Hiroshi Okamoto
    Pages 269-299
  14. Stevan Rakovic, Derek A Terrar
    Pages 319-341
  15. Pin-Lan Li, Ai-Ping Zou, William B. Campbell
    Pages 343-363
  16. Uh-Hyun Kim, Myung-Kwan Han, Chang-Yeol Yim
    Pages 397-407
  17. Thomas A. White, Deepak A. Deshpande, Soner Dogan, Reynold A. Panettieri, Timothy F. Walseth, Mathur S. Kannan
    Pages 427-449
  18. Back Matter
    Pages 451-460

About this book

Introduction

In the past decade we have witnessed the birth and maturing of a field of research centering on the Ca2+ signaling functions of cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), which structures and mechanisms of action are truly unique among all Ca2+ messengers. A wide range of physiological functions are now known to be mediated by them in cells spanning three biological kingdoms from protist, plant to animal. This is the first book devoted entirely to the field. The story behind the emergence of the field is told and followed by comprehensive reviews of the enzymology, regulations and gene structures of ADP-ribosyl cyclases responsible for metabolizing cADPR and NAADP. Also covered is some of the current methodology developed for and widely used in the field. The rest of the book focuses on and details the Ca2+ signaling mechanisms and specific physiological functions of these two messengers in various cellular systems.

Keywords

Calcium Nucleotide metabolism pharmacology research synthesis

Editors and affiliations

  • Hon Cheung Lee
    • 1
  1. 1.MinneapolisUSA

Bibliographic information