Tumor Metabolome Targeting and Drug Development

  • Steven Kanner

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Paul M. Bingham, Shawn D. Stuart, Zuzana Zachar
    Pages 7-27
  3. Teresa L. Serafim, Paulo J. Oliveira
    Pages 29-73
  4. Ashleigh Pulkoski-Gross, Nikki A. Evensen, Jian Cao
    Pages 75-108
  5. Maria I. Vaccaro, Claudio D. Gonzalez, Silvia Alvarez, Alejandro Ropolo
    Pages 131-156
  6. Kevin Marks, Charles Kung
    Pages 157-180
  7. Katarina Färnegårdh, Maria Shoshan, Lars Ährlund-Richter
    Pages 181-195
  8. Back Matter
    Pages 197-198

About this book


In this volume, the major metabolic alterations identified in cancer and tumor-associated cells are explored, including discussions of former and emerging approaches to drug development in targeting cancer cell metabolism. 

The metabolic network in cells promotes the generation of both energy and biomass needed for them to grow, divide and differentiate.  However, the metabolism of malignant cells generally varies from that of normal cells.  These differences provide a platform for the discovery of new approaches to targeting potential vulnerabilities in cancer cells for therapeutic options  Some of the significant changes that occur involve ATP production and consumption that modulates the ATP to ADP ratio, hypoxia and the effects of reactive oxygen species on glycolysis, regulation of mitochondrial respiration, induction and suppression of autophagy, and the Warburg effect and “reverse” Warburg effect--these topics and more are discussed in this volume.  


drug development targeting tumor tumor metabalome

Editors and affiliations

  • Steven Kanner
    • 1
  1. 1.Vice President, BiologyArrowhead Research Corporation465 Science Drive, 53711 MadisonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2014
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine
  • Print ISBN 978-1-4614-9544-4
  • Online ISBN 978-1-4614-9545-1
  • Series Print ISSN 2196-9906
  • Series Online ISSN 2196-9914
  • Buy this book on publisher's site