Proteases in Health and Disease

  • Sajal Chakraborti
  • Naranjan S. Dhalla

Part of the Advances in Biochemistry in Health and Disease book series (ABHD, volume 7)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Molecular and Biochemical Aspects of Proteases

    1. Front Matter
      Pages 1-1
    2. Krishna Samanta, Pulak Kar, Tapati Chakraborti, Sajal Chakraborti
      Pages 3-19
    3. Sreejit Parameswaran, Sujeet Kumar, Rajendra K. Sharma
      Pages 33-48
    4. Soni Shaikh, Animesh Chowdhury, Alok K. Banerjee, Jaganmay Sarkar, Sajal Chakraborti
      Pages 49-62
    5. André L. S. Santos, Lys A. Braga-Silva, Bianca A. Silva, Vanila F. Palmeira, Roberta S. Valle, Érika A. Abi-chacra et al.
      Pages 89-119
    6. Kailash C. Pandey
      Pages 121-134
    7. Partha Das, MD Nur Alam, Tripti De, Tapati Chakraborti
      Pages 135-161
    8. Ashok D. Pehere, Andrew D. Abell
      Pages 181-192
  3. Involvement of Proteases in Disease Processes

    1. Front Matter
      Pages 193-193
    2. Soumitra Roy, Tapati Chakraborti, Animesh Chowdhury, Kuntal Dey, Sajal Chakraborti
      Pages 195-213
    3. Sumit Rathore, Shaifali Jain, MohD Asad, Gaurav Datta, Pawan Malhotra, Asif Mohmmed
      Pages 215-242
    4. Amit Pal, Sun Nyunt Wai
      Pages 243-256
    5. Surbhi Saini, Tal Schiller, Andrew Wu, Chava Kimchi-Sarfaty
      Pages 257-276
    6. Stav Simsa-Maziel, Dalit Sela-Donenfeld, Efrat Monsonego-Ornan
      Pages 289-312
    7. Srijita Dhar, Bimal K. Ray, Alpana Ray
      Pages 313-325
    8. Dario Siniscalco, Nicola Antonucci
      Pages 327-333
    9. Vaishali M. Patil, Neeraj Masand, Satya Prakash Gupta
      Pages 335-360
    10. Kaustav Chakraborty, Arindam Bhattacharyya
      Pages 361-385
    11. Raja B. Singh, Vijayan Elimban, Davinder S. Jassal, Naranjan S. Dhalla
      Pages 387-399
  4. Back Matter
    Pages 401-403

About this book


Proteases form one of the largest and most diverse families of enzymes known. Once considered primarily as “enzymes of digestion,” it is now clear that proteases are involved in every aspect of cellular function. Members of the diverse families of proteases act to promote cellular proteolysis found in nature, and their deregulation may result in different pathophysiological conditions, such as tumor progression, vascular remodeling, atherosclerotic plaque progression, ulcer, rheumatoid arthritis, and Alzheimer’s disease. Many micro-organisms require proteases for replication or use proteases as virulence factors, which have facilitated the development of protease-targeted therapies for a variety of parasitic diseases.

Proteases in Health and Disease represents a comprehensive overview of the fascinating field of proteases by various renowned experts, and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. Part A, Molecular and Biochemical Aspects of Proteases, illustrates some of the major proteases, such as calpains, matrix metalloproteases, fibrinolytic serine proteases, and aspartic proteases, which play a significant role in a variety of pathologies and may be a target for therapy either by their up regulation or down regulation. Part B, Involvement of Proteases in Diseases Processes, deals with the functional roles of the individual proteases in the progression of diseases such as cardiovascular and inflammatory lung disease, malaria, cholera, autism spectrum disorder, hepatitis, and ischemia-reperfusion injury induced cardiac diseases. With this multi-disciplinary scope, the book bridges the gap between fundamental research and biomedical and pharmaceutical applications, making this a thought-provoking reading for basic and applied scientists engaged in biomedical research.


About the Editors:

Dr. Sajal Chakraborti is a Senior Professor of Biochemistry at the University of Kalyani, West Bengal, India. His research covers the role of proteases in regulating pulmonary vascular tone under oxidant- and calcium-signaling phenomena. He has been engaged in teaching and research in biochemistry for the past 35 years.

Dr. Naranjan Dhalla is a Distinguished Professor at the University of Manitoba, Winnipeg, Canada.  His expertise includes the subcellular and molecular basis of heart function in health and disease. He has been engaged in multidisciplinary research and education for promoting the scientific basis of cardiology, as well as training of professional manpower for combating heart disease for over 40 years.



Biochemistry Proteases Signal transduction

Editors and affiliations

  • Sajal Chakraborti
    • 1
  • Naranjan S. Dhalla
    • 2
  1. 1.Department of Biochemistry and BiophysicsUniversity of KalyaniKalyaniIndia
  2. 2.Institute of Cardiovascular SciencesUniversity of Manitoba, St. Boniface Hospital Research CentreWinnipegCanada

Bibliographic information