Role of Proteases in Cellular Dysfunction

  • Naranjan S. Dhalla
  • Sajal Chakraborti

Part of the Advances in Biochemistry in Health and Disease book series (ABHD, volume 8)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Proteases and Neural Disorders

    1. Front Matter
      Pages 1-1
    2. Nicole Trager, Azizul Haque, Swapan K. Ray, Arabinda Das, Naren L. Banik
      Pages 3-15
    3. Alakananda Goswami, Prosenjit Sen, Kuladip Jana, Sanghamitra Raha
      Pages 47-66
    4. Sibani Sarkar, Somnath Chatterjee, Snehasikta Swarnakar
      Pages 67-91
    5. Ji Hae Seo, Shuzhen Guo, Josephine Lok, Deepti Navaratna, Changhong Xing, Eng H. Lo
      Pages 93-102
    6. Avi Bar, Irit Shoval, Efrat Monsonego-Ornan, Dalit Sela-Donenfeld
      Pages 103-126
  3. Proteases and Cancer

    1. Front Matter
      Pages 127-127
    2. Shudong Zhu, Zhoufang Li
      Pages 129-145
    3. Ajay K. Chaudhary, Anita H. Nadkarni, Shruti Pandya, Kanjaksha Ghosh
      Pages 147-158
    4. Pushpak Bhattacharjee, Minakshi Mazumdar, Deblina Guha, Gaurisankar Sa
      Pages 159-186
    5. Shravanti Mukherjee, Argha Manna, Minakshi Mazumdar, Tanya Das
      Pages 187-212
    6. Sindhuri Upadrasta, Neeru Saini
      Pages 227-244
  4. Proteases and Cardiovascular Defects

    1. Front Matter
      Pages 245-245
    2. Karina Di Gregoli, Jason L. Johnson
      Pages 247-262
    3. Alejandro F. Prado, Michele M. Castro, Raquel F. Gerlach
      Pages 279-293
    4. Erin R. Mandel, Cassandra Uchida, Tara L. Haas
      Pages 295-319
    5. Balraj Mittal, Avshesh Mishra, Anshika Srivastava, Naveen Garg
      Pages 321-334
    6. Soumitra Roy, Tapati Chakraborti, Soni Shaikh, Animesh Chowdhury, Sajal Chakraborti
      Pages 351-364
    7. Naranjan S. Dhalla, Vijayan Elimban, Davinder S. Jassal
      Pages 365-381
    8. Aastha Chhabra, Shrey Kohli, Vibha Rani
      Pages 407-426
  5. Back Matter
    Pages 459-462

About this book


It is now well known that proteases are found everywhere, in viruses and bacteria as well as in all human, animal and plant cells, and play a role in a variety of biological functions ranging from digestion, fertilization, development to senescence and death. Under physiological conditions the ability of proteases is regulated by endogenous inhibitors. However, when the activity of proteases is not regulated appropriately, disease processes can result, as seen in Alzheimer’s disease, cancer metastasis and tumor progression, inflammation and atherosclerosis. Thus it is evident that there is an absolute need for a tighter control of proteolytic activities in different cells and tissues.

Aimed at graduate students and researchers with an interest in cellular proteolytic events, Role of Proteases in Cellular Dysfunctions is the second book on Proteases in this series. The book consists of three parts in specified topics based on current literatures for a better understanding for the readers with respect to their subject-wise interests. The first section of this book covers a brief idea about the neuronal disorders and the involvement of proteases such as calpains, caspases and matrix metalloproteases (MMPs). The second section covers the deadly disease cancer and its relation to ubiquitin-proteosomal system, MMPs and serine proteases. The last section is about the role of proteases such as calpains, MMPs and serine protease as well as urokinase type plasminogen activator receptor (uPAR) in causing cardiovascular defects.


antiproteases cancer cardiovascular diseases cell dysfunction diabetes proteases

Editors and affiliations

  • Naranjan S. Dhalla
    • 1
  • Sajal Chakraborti
    • 2
  1. 1.St. Boniface Hosp. Research, Univ. of Ma Institute of Cardiovascular SciencesWinnipegCanada
  2. 2.Dept of Biochemistry and BiophysicsUniversity of KalyaniKalyaniIndia

Bibliographic information