Systems Analysis of Human Multigene Disorders

  • Natalia Maltsev
  • Andrey Rzhetsky
  • T. Conrad Gilliam

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 799)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Christopher E. Mason, Sandra G. Porter, Todd M. Smith
    Pages 15-38
  3. Dinanath Sulakhe, Sandhya Balasubramanian, Bingqing Xie, Eduardo Berrocal, Bo Feng, Andrew Taylor et al.
    Pages 39-67
  4. Cheng Zhu, Chao Wu, Bruce J. Aronow, Anil G. Jegga
    Pages 69-84
  5. Back Matter
    Pages 119-122

About this book


Understanding the genetic architecture underlying complex multigene disorders is one of the major goals of human genetics in the upcoming decades. Advances in whole genome sequencing and the success of high throughput functional genomics allow supplementing conventional reductionist biology with systems-level approaches to human heredity and health as systems of interacting genetic, epigenetic, and environmental factors. This integrative approach holds the promise of unveiling yet unexplored levels of molecular organization and biological complexity. It may also hold the key to deciphering the multigene patterns of disease inheritance.

Editors and affiliations

  • Natalia Maltsev
    • 1
  • Andrey Rzhetsky
    • 2
  • T. Conrad Gilliam
    • 3
  1. 1.University of ChicagoChicagoUSA
  2. 2.University of ChicagoChicagoUSA
  3. 3.University of ChicagoChicagoUSA

Bibliographic information