Molecular Pathogenesis of Colorectal Cancer

  • Kevin M. Haigis, Ph.D.

Table of contents

  1. Front Matter
    Pages i-viii
  2. William Hankey, Joanna Groden
    Pages 1-24
  3. Jatin Roper, Kenneth E. Hung
    Pages 25-65
  4. Maria José Oliveira, Sérgia Velho
    Pages 67-105
  5. Katherine H. Pedone, Jennifer L. Sells, Channing J. Der
    Pages 121-156
  6. Jihye Yun, George Poulogiannis, Evan T. Brower, Samuel Klempner, Lewis L. Cantley
    Pages 157-199
  7. William M. Grady
    Pages 201-230
  8. Franklin W. Huang, Laura B. Kleiman, Theodore S. Hong
    Pages 231-245
  9. Nickolas Papadopoulos
    Pages 247-265
  10. Jihun Kim, Adam J. Bass
    Pages 267-287
  11. Back Matter
    Pages 309-316

About this book


For more than two decades, colorectal cancer has served as the paradigm for the cooperative activity of oncogenes and tumor suppressor genes in cancer initiation and progression. The depth of molecular characterization for this disease is unparalleled, with specific mutations correlated to each histologic stage of progression from normal colon to malignant colorectal cancer. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies.

This book explores the past, present, and future of colorectal cancer genetics, with particular emphasis on how knowledge of the molecular pathogenesis of the disease leads to the development of novel therapeutic strategies. Individual chapters discuss general topics, such as genomic instability and inflammation, or else specific pathways, for example RAS, PI3K, and TGF-b, that play a role in colorectal cancer progression.

Editors and affiliations

  • Kevin M. Haigis, Ph.D.
    • 1
  1. 1.Molecular Pathology UnitHarvard Medical SchoolCharlestownUSA

Bibliographic information