Molecular Genetics of Inflammatory Bowel Disease

  • Mauro D'Amato
  • John D Rioux

Table of contents

  1. Front Matter
    Pages i-xiii
  2. The Foundation of IBD Genetics, Human and Animal Studies

    1. Front Matter
      Pages 1-1
    2. Xinjun Cindy Zhu, Richard P. MacDermott
      Pages 3-21
    3. Emiko Mizoguchi, Atsushi Mizoguchi, Atul K. Bhan
      Pages 45-83
  3. The Genetic and Molecular Makeup of Inflammatory Bowel Disease

    1. Front Matter
      Pages 85-85
    2. Jeffrey C. Barrett, Mark J. Daly
      Pages 87-97
    3. Andre Franke, Miles Parkes
      Pages 99-118
    4. Mauro D’Amato, Catherine Labbé, John D. Rioux
      Pages 119-134
    5. Charlie W. Lees, Alexandra Zhernakova
      Pages 135-150
    6. Isabelle Cleynen, Séverine Vermeire
      Pages 151-169
    7. Robert Häsler, Stefan Schreiber, Stephan Beck, Philip Rosenstiel
      Pages 171-187
  4. Pathogenetic Pathways in Inflammatory Bowel Disease

    1. Front Matter
      Pages 189-189
    2. Maria Kaparakis-Liaskos, Dana J. Philpott
      Pages 191-217
    3. Kevin J. Maloy
      Pages 219-240
    4. Natalia B. Nedelsky, Petric Kuballa, Adam B. Castoreno, Ramnik J. Xavier
      Pages 241-264
    5. Stefan Koch, Asma Nusrat, Charles A. Parkos
      Pages 265-280
    6. Nouara Lhocine, Philippe J. Sansonetti
      Pages 281-305
    7. Matthias A. Engel, Markus F. Neurath
      Pages 307-326
  5. Concluding Remarks and Future Perspectives

    1. Front Matter
      Pages 327-327
  6. Back Matter
    Pages 341-343

About this book


Inflammatory bowel disease (IBD) affects 1% of people worldwide. This condition is partly inherited, and genetic research has made enormous progress during the last few years, providing important insight into disease pathogenesis. This book provides a concise but complete overview of existing knowledge, with particular focus on the molecular and genetic mechanisms at the basis of IBD.

Invited experts, at the frontline of IBD research, introduce basic concepts in the pathophysiology of IBD and its two major forms Crohn’s disease and ulcerative colitis, provide a historical perspective and highlight latest discoveries of IBD genetic research, describe how this information has helped to unravel novel pathogenetic pathways, and formulate a vision for future investigations and their clinical application in IBD.

State-of-the-art information contained in this book is an exceptional resource for all those in the biomedical field with a specific interest in IBD, including basic scientists, gastroenterologists, GI specialist doctors and research nurses, but also medical and biomedical students.

Editors and affiliations

  • Mauro D'Amato
    • 1
  • John D Rioux
    • 2
  1. 1.Department of Biosciences and NutritionKarolinska InstituteStockholmSweden
  2. 2.Research CenterMontreal Heart InstituteMontrealCanada

Bibliographic information