© 2014

Necrotic Cell Death

  • Han-Ming Shen
  • Peter Vandenabeele

Part of the Cell Death in Biology and Diseases book series (CELLDEATH)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Andreas Linkermann, Tom Vanden Berghe, Nozomi Takahashi, Ulrich Kunzendorf, Stefan Krautwald, Peter Vandenabeele
    Pages 1-21
  3. Ting Wu, Wanze Chen, Jiahuai Han
    Pages 45-55
  4. John Silke, David Vaux
    Pages 57-77
  5. Maurice Darding, Henning Walczak
    Pages 79-97
  6. David Wallach, Tae-Bong Kang, Akhil Rajput, Seung-Hoon Yang, Jin-Chul Kim, Beata Toth et al.
    Pages 117-133
  7. Michael J. Morgan, You-Sun Kim
    Pages 135-162
  8. Yongjun Fan, Wei-Xing Zong
    Pages 163-175
  9. Kenta Moriwaki, Francis Ka-Ming Chan
    Pages 177-194
  10. Han-Ming Shen, Patrice Codogno
    Pages 233-252
  11. Vassiliki Nikoletopoulou, Nektarios Tavernarakis
    Pages 275-294
  12. Dana E. Christofferson, Ying Li, Junying Yuan
    Pages 295-318
  13. Colleen R. McNamara, Alexei Degterev
    Pages 319-334
  14. Sasker Grootjans, Vera Goossens, Peter Vandenabeele, Tom Vanden Berghe
    Pages 335-361
  15. Back Matter
    Pages 363-397

About this book


This essential volume in the Cell Death in Biology and Diseases series presents comprehensive coverage of necrosis from recognized experts at leading academic and medical institutions around the world, thus keeping pace with the emerging research interest in necrosis. Starting with discussion of basic concepts and the molecular mechanisms of necrosis, this book looks first at the several forms of necrotic cell death that have been identified, including necroptosis, autophagic cell death, and PARP-mediated cell death.  As necrotic cell death is increasingly known to play a critical role in many physiological processes, the next chapters discuss its effect on metabolism, inflammation, immunity, and development. Necrotic cell death is closely implicated in human diseases like cancer so the next chapters examine its relevance to human diseases, and final chapters cover methodologies for measuring necrosis.


Apoptosis Cell death Necrosis Necrotic cell death Oxidative stress

Editors and affiliations

  • Han-Ming Shen
    • 1
  • Peter Vandenabeele
    • 2
  1. 1.Department of PhysiologyNational University of Singapore Yong Loo Lin School of MedicineSingaporeSingapore
  2. 2.Department of Biomedical Molecular Biology (UGent)VIB/University of Ghent Inflammation Research Center (VIB)ZwijnaardeBelgium

About the editors

Dr. Han-Ming Shen is currently Associate Professor in the Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore. He received his Ph.D. from the National University of Singapore and holds a Master of Medicine from Zhejiang Medical University, China. Winner of several academic and scientific awards, Dr. Shen’s main research interests include autophagy in cell death and cancer, involvement of reactive oxygen/nitrogen species and oxidative stress in cell death signaling pathways (apoptotic and non-apoptotic cell death), and antioxidants and natural products as anti-cancer agents.

Dr. Peter Vandenabeele obtained his PhD in Biology in the lab of Prof. Walter Fiers at Ghent University in Belgium. Currently, he is a Primary Investigator at the Flanders Institute for Biotechnology (VIB) and a Senior Professor at Ghent University where he also served for ten years as Director of the Bachelor’s and Master’s program in Biochemistry and Biotechnology and still serves on the Board of Governors.  His research focuses on molecular mechanisms of cell death and inflammation with focus on necrotic cell death which is studied in an integrated way at biochemical, cell biological and experimental disease level. Dr. Vandenabeele has also twice been chairman of the Euroconference on Apoptosis, organized by the European Cell Death Organization (ECDO).

Bibliographic information