Complex Systems and Computational Biology Approaches to Acute Inflammation

  • Yoram Vodovotz
  • Gary An

Table of contents

  1. Front Matter
    Pages i-xi
  2. Complex Systems Methods and Applications

    1. Front Matter
      Pages 9-9
    2. Gilles Clermont
      Pages 11-28
    3. Scott Christley, Gary An
      Pages 29-49
    4. Patrick R. Norris
      Pages 51-77
    5. Thomas E. Dick, Rishi R. Dhingra, Yee-Hsee Hsieh, Mikkel Fishman, Farhad Kaffashi, Kenneth A. Loparo et al.
      Pages 79-99
  3. Translational Modeling of Sepsis and Trauma

    1. Front Matter
      Pages 101-101
    2. Kent R. Zettel II, Timothy R. Billiar
      Pages 103-124
    3. Jeremy D. Scheff, Steve E. Calvano, Ioannis P. Androulakis
      Pages 125-141
    4. Nabil Azhar, Qi Mi, Cordelia Ziraldo, Marius Buliga, Gregory M. Constantine, Yoram Vodovotz
      Pages 143-157
    5. Yoram Vodovotz, John Bartels, Gary An
      Pages 159-170
  4. Translational Modeling of Wound Healing

    1. Front Matter
      Pages 171-171
    2. Sashwati Roy, Amitava Das, Chandan K. Sen
      Pages 173-183
    3. Jordan R. Stern, Cordelia Ziraldo, Yoram Vodovotz, Gary An
      Pages 209-228
  5. Translational Modeling of Host-Pathogen Interactions

    1. Front Matter
      Pages 229-229
    2. Julia Arciero, Jared Barber, Moses Kim
      Pages 231-264
    3. Yoram Vodovotz, Nabil Azhar, Natasa Miskov-Zivanov, Marius Buliga, Ruben Zamora, Bard Ermentrout et al.
      Pages 265-279
  6. Future Perspectives: Translation to Implementation

  7. Back Matter
    Pages 289-291

About this book


The Translational Dilemma, the difficulty in achieving effective translation of basic mechanistic biomedical knowledge into effective therapeutics, is the greatest challenge in biomedical research. Nowhere is this more apparent than in understanding and manipulating the acute inflammatory response in the settings of sepsis, trauma/hemorrhage, wound healing, and related processes. The burgeoning fields of complex systems analysis and computational biology offer researchers a pathway towards addressing the Translational Dilemma. Complex Systems and Computational Biology Approaches to Acute Inflammation presents the current state of the art of multi-disciplinary and systems-oriented research approaches to complex diseases arising from and driven by the acute inflammatory response. The chapters in this volume provide an introduction to different types of computational modeling, and how these methods can be applied to specific inflammatory diseases, with a focus on providing readers with a roadmap for integrating advanced mathematical and computational techniques with traditional experimental methods. By presenting the role of computational modeling as an integrated component of the research process, Complex Systems and Computational Biology Approaches to Acute Inflammation offers a window into the future of biomedical research.


inflammation modeling systems biology

Editors and affiliations

  • Yoram Vodovotz
    • 1
  • Gary An
    • 2
  1. 1.University of Pittsburgh Inflammation and Regenerative ModelingPittsburghUSA
  2. 2.University of Chicago Medical Center MC 5094ChicagoUSA

Bibliographic information