Stearoyl-CoA Desaturase Genes in Lipid Metabolism

  • James M. Ntambi, Ph.D.

Table of contents

  1. Front Matter
    Pages i-xi
  2. Satish Parimoo, Pappas Apostolos
    Pages 13-25
  3. Nishan Sudheera Kalupahana, Thilak Jayalath, Shu Wang, Naima Moustaid-Moussa
    Pages 49-60
  4. Nishan Sudheera Kalupahana, Shu Wang, Shaikh M. Rahman, Naima Moustaid-Moussa
    Pages 61-71
  5. Pawel Dobrzyn, Agnieszka Dobrzyn
    Pages 85-101
  6. Joseph Stevens, Matthew W. Hulver
    Pages 103-118
  7. Jennifer L. Cantley, Lucas M. O’Neill, James M. Ntambi, Michael P. Czech
    Pages 119-130
  8. Silvia Graciela Altabe, María Cecilia Mansilla, Diego de Mendoza
    Pages 209-231
  9. Back Matter
    Pages 233-239

About this book

Introduction

James Ntambi has gathered top authors to write about the remarkable growth of research on the role of the stearoyl-CoA desaturase (SCD) genes in metabolism in different species including human. The book shows that beginning with simple cellular models of differentiation a broad and comprehensive analysis of the SCD gene family in a number of species and biological systems has been carried out over the course of the last twenty five years. SCD is a central enzyme in lipid metabolism that synthesizes monounsaturated fatty acids (MUFA) from saturated fatty acid precursors. At first glance, SCD would be considered a housekeeping enzyme because its product oleate is a well-known MUFA that is abundant in many dietary sources and tissue lipids.

A particular highlight in the chapters of the book is that MUFAs may have signaling properties that regulate metabolism. For example, a proper ratio of saturated to MUFA contributes to membrane fluidity, and oleate has also been implicated as a mediator of signal transduction, cellular differentiation and metabolic homeostasis. It is also highlighted that SCD-1 repression mediates the metabolic effects of the hormone leptin. Conditional alleles and corresponding tissue-specific knockout mouse models for many of the SCD gene isorfms have provided a wealth of information on not only tissue-specific fatty acid metabolism but also the key transcription factors that regulate SCD expression under a variety of metabolic and genetic backgrounds. The studies described indicate that control of SCD expression occurs via a series of complex signal transduction schemes making SCD one of the most highly studied lipogenic gene families to date.

Keywords

Endocrinology Gene Regulation Lipids Metabolism SCD Genes

Editors and affiliations

  • James M. Ntambi, Ph.D.
    • 1
  1. 1.Departments of Biochemistry and Nutritional SciencesUniversity of Wisconsin-MadisonMadisonUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-7969-7
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-7968-0
  • Online ISBN 978-1-4614-7969-7
  • About this book