© 2013

Immuno Systems Biology

A macroscopic approach for immune cell signaling


Part of the Systems Biology book series (SYSTBIOL, volume 3)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Kumar Selvarajoo
    Pages 1-11
  3. Kumar Selvarajoo
    Pages 25-33
  4. Kumar Selvarajoo
    Pages 35-52
  5. Kumar Selvarajoo
    Pages 53-64
  6. Kumar Selvarajoo
    Pages 65-74
  7. Kumar Selvarajoo
    Pages 75-86
  8. Kumar Selvarajoo
    Pages 87-103
  9. Kumar Selvarajoo
    Pages 131-140
  10. Kumar Selvarajoo
    Pages 141-142
  11. Back Matter
    Pages 143-146

About this book


Technological advances of modern biology have generated high volumes of ‘omics’ data. The natural precedence has been to put the complex information together, so that it will lead to spectacular scientific discoveries and medical breakthroughs. In this light, tremendous efforts worldwide are reshaping biological research by integrating with information science. Despite the ‘systems biology’ efforts, for major illnesses, such as proinflammatory diseases and cancer, there is clear clinical evidence that even the most current therapies, at best, control transient response and subdue to the robust adaptability of the disease state. Hence, there is a need for system-levels understanding of bio-complexity.

Kumar Selvarajoo brings attention to fundamental questions governing sophisticated behaviors of the mammalian immune system. To tackle some of the complex issues, the book introduces perturbation-response approach, using the law of physics (mass flow conservation), as a means to interpret the dynamic response of major proinflammatory pathways of the immune and cancer cells. Overall, the book provides an illustrated journey that explains biological cell signaling in simple terms.



Authors and affiliations

  1. 1.Keio University Inst. Advanced BiosciencesTsuruoka, YamagataJapan

Bibliographic information