Biophysics of the Failing Heart

Physics and Biology of Heart Muscle

  • R. John Solaro
  • Jil C. Tardiff

Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

Table of contents

  1. Front Matter
    Pages i-vi
  2. R. John Solaro, Jil C. Tardiff
    Pages 1-4
  3. Aleksey V. Zima, Dmitry Terentyev
    Pages 5-36
  4. Man Liu, Vikram Maddikunta Brahmanandam, Samuel C. Dudley Jr.
    Pages 63-90
  5. Elizabeth McNally
    Pages 123-140
  6. Allen M. Samarel, Yevgeniya Koshman, Erik R. Swanson, Brenda Russell
    Pages 141-174
  7. Brian R. Anderson, Henk L. Granzier
    Pages 201-223
  8. Jillian N. Simon, Jil C. Tardiff, Beata M. Wolska
    Pages 225-247
  9. Back Matter
    Pages 249-253

About this book


Biophysics of the Failing Heart considers major biophysical mechanisms for why hearts responding to stressors enter into maladaptive processes, eventually leading to an inability of the heart to respond efficiently to hemodynamic loads--especially during exercise. The book describes biophysical techniques that have been applied to determine the triggers for the heart failure process, as well as the mechanisms for sustaining the disorders. These techniques include measurements of active and passive mechanical properties and hemodynamics at levels of organization ranging from molecules to hearts beating in situ. Biophysical concepts and approaches are also applied to determination of signaling and signal transduction, energetics, ionic currents, transport processes, electro-chemical and chemo-mechanical coupling.
Modern research approaches and clinical understanding of heart failure demands integration of multiple aspects of the disorders. By its emphasis on biophysical aspects of a prevalent clinical condition, this monograph is unique in its perspective and focus, and will be of value to clinicians and researchers at all levels.


Biophysics of Heart Failure Ca-homeostasis and Heart Failure Energy Metabolism in Heart Failure calcium homeostasis cardiac decompensation cardiac energetics excitation contraction coupling extra-cellular matrix

Editors and affiliations

  • R. John Solaro
    • 1
  • Jil C. Tardiff
    • 2
  1. 1.Dept. of Physiology & BiophysicsUniversity of Illinois at ChicagoChicagoUSA
  2. 2.University of ArizonaTucsonUSA

Bibliographic information