Adipose Tissue and Cancer

  • Mikhail G. Kolonin

Table of contents

  1. Front Matter
    Pages i-viii
  2. Nikki A. Ford, John DiGiovanni, Stephen D. Hursting
    Pages 1-14
  3. Charles Bellows, Herbert Tilg
    Pages 15-32
  4. Linda Vona-Davis, David P. Rose
    Pages 33-51
  5. Karen H. Lu, Ann H. Klopp, Pamela T. Soliman, Rosemarie E. Schmandt
    Pages 53-69
  6. Gilberto Paz-Filho, Ameet Kumar Mishra, Julio Licinio
    Pages 71-97
  7. Amitabha Ray, Margot P. Cleary
    Pages 99-119
  8. Ines Martin-Padura, Patrizia Mancuso, Francesco Bertolini
    Pages 147-163
  9. Ted D. Adams, Jessica L. J. Greenwood, Steven C. Hunt
    Pages 165-187
  10. Back Matter
    Pages 189-190

About this book

Introduction

The pathophysiology underlying the relationship between obesity and cancer is complex and incompletely understood. Progression of certain cancers has been shown to accelerate in obese patients irrespective of their lifestyle and diet. Because obesity is manifested by overgrowth of white adipose tissue, it has been proposed that adipose tissue has a direct effect on cancer progression.

Adipose tissue is composed of several types of cells secreting numerous soluble factors collectively termed adipokines. In addition, infiltration of the immune system cells in obesity leads to increased production of a number of inflammatory factors by adipose tissue, thus contributing to the establishment of the metabolic syndrome. Endocrine signaling by adipose tissue-derived molecules has been shown to promote cancer in animal models, matching clinical associations. Recent studies have shown that cells from adipose tissue are capable of trafficking to tumors, thus enabling paracrine action of adipokines from within the tumor microenvironment. Increased tumor vascularization, immune system suppression and direct effects on malignant cell survival and proliferation have been investigated as mechanisms regulated by adipokines.

This volume will discuss clinical and experimental data pointing to the role of adipose tissue in cancer and to dissect individual mechanisms through which adipose tissue excess or restriction could influence cancer progression.

Keywords

adipocytes adipokines adiposity metabolic dysregulation white adipose tissue

Editors and affiliations

  • Mikhail G. Kolonin
    • 1
  1. 1.Science Center at Houston, Inst. Molecular MedicineUniversity of TexasHoustonUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-7660-3
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-7659-7
  • Online ISBN 978-1-4614-7660-3
  • About this book