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Resistance to Immunotherapeutic Antibodies in Cancer

Strategies to Overcome Resistance

  • Benjamin Bonavida

Part of the Resistance to Targeted Anti-Cancer Therapeutics book series (RTACT, volume 2)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Yangyang Wang, Francesco Sabbatino, Ling Yu, Elvira Favoino, Xinhui Wang, Matteo Ligorio et al.
    Pages 25-47
  3. Emily L. Williams, Sean H. Lim, Stephen A. Beers, Peter W. Johnson, Jonathan C. Strefford, Martin J. Glennie et al.
    Pages 49-71
  4. Back Matter
    Pages 201-202

About this book

Introduction

The current application of antibody-meditated targeted therapy against cancer has resulted in significant objective clinical responses, prolongation of survival and even cures. More than 20 mAbs have been approved for human use targeting a range of different cancers. However, a major drawback of mAb therapeutics is that a subset of patients does not initially respond and another initially responding subset develops resistance to further treatments. At the present time, there are no effective therapies for these subsets of cancer patients. The analyses of underlying mechanisms responsible for resistance are necessary to develop and generate new targeted therapies that overcome the resistance.

Resistance to Immunotherapeutic Antibodies in Cancer: Strategies to Overcome Resistance is a timely volume that deals with various mechanisms of resistance to anti-cancer mAbs therapeutics as well as it deals with novel approaches to overcome resistance. The reviews in this volume are written by highly qualified, established and experienced leaders in the field of resistance to anti-cancer mAbs.

Keywords

Rituximab antibody-drug conjugates cancer drug resistance mABs monoclonal antibody

Editors and affiliations

  • Benjamin Bonavida
    • 1
  1. 1.Molecular GeneticsUniversity of California, Los Angeles Dept. Microbiology, Immunology &Los AngelesUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-7654-2
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-7653-5
  • Online ISBN 978-1-4614-7654-2
  • Series Print ISSN 2196-5501
  • Series Online ISSN 2196-551X
  • Buy this book on publisher's site