Hyperglycemia, Diabetes, and Vascular Disease

  • Neil Ruderman
  • Joseph Williamson
  • Michael Brownlee

Part of the Clinical Physiology Series book series (CLINPHY)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Epidemiology and Physiology

    1. Front Matter
      Pages 1-1
    2. Neil B. Ruderman, Sandeep Gupta, Ilene Sussman
      Pages 3-20
    3. Peter W. F. Wilson, William B. Kannel
      Pages 21-29
    4. Richard A. Cohen, Belay Tesfamariam
      Pages 48-58
  3. Polyols, myo-Inositol, and Signal Transduction

  4. Glycation Products and Glycosoaminoglycans

    1. Front Matter
      Pages 195-195
    2. Timothy J. Lyons, Suzanne R. Thorpe, John W. Baynes
      Pages 197-217
    3. Aristidis S. Charonis, Effie C. Tsilibary, Leo T. Furcht
      Pages 243-262
    4. David J. Klein
      Pages 263-281
  5. Back Matter
    Pages 283-300

About this book


There are over 12 million people with diabetes in the U.S. Blindness, renal failure, and coronary heart disease are the three most frequent complications of late-stage diabetes, and diabetic patients are at greater risk for developing these conditions than the rest of the population. This book examines the link between hyperglycemia and micro- and macro- vascular disease in diabetes. The authors review clinical, epidemiological, and biochemical evidence that high levels of blood glucose produce metabolic and biochemical alterations in vascular walls. These alterations in turn lead to abnormalities in vascular structure and, ultimately, function. Although there are differences in the pathogenesis of these two types of vascular disease, the emphasis in the book is on the common mechanisms by which hyperglycemia produces vascular alterations. This work is unique in providing an integrated picture of the effects of hyperglycemia on vascular metabolism, function, and disease. Implications for therapy are also discussed. Hyperglycemia, Diabetes and Vascular Disease is based on a 1989 FASEB symposium offered by the American Physiological Society, and is a volume in the Society's Clinical Physiology Series.


Diabetes Diabetes mellitus Hyperglycemia Vascular Disease endothelium metabolism physiology signal transduction

Editors and affiliations

  • Neil Ruderman
    • 1
  • Joseph Williamson
    • 2
  • Michael Brownlee
    • 3
  1. 1.Diabetes and Metabolism Unit, Evans Memorial Department of Clinical Research and Department of PhysiologyBoston University School of MedicineBostonUSA
  2. 2.Department of PathologyWashington University School of MedicineSt. LouisUSA
  3. 3.Diabetes Research Center and Departments of Medicine and PathologyAlbert Einstein College of MedicineBronxUSA

Bibliographic information