A Case Approach to Perioperative Drug-Drug Interactions

  • Catherine Marcucci
  • Michael P. Hutchens
  • Erica D. Wittwer
  • Toby N. Weingarten
  • Juraj Sprung
  • Wayne T. Nicholson
  • Kirk Lalwani
  • David G. Metro
  • Randal O. Dull
  • Christopher E. Swide
  • F. Jacob Seagull
  • Jeffrey R. Kirsch
  • Neil B. Sandson

Table of contents

  1. Front Matter
    Pages i-xlviii
  2. Introduction to Drug–Drug Interactions

    1. Front Matter
      Pages 1-1
    2. F. Jacob Seagull, Christopher E. Swide, Catherine Marcucci
      Pages 3-8
    3. Erica D. Wittwer, Wayne T. Nicholson
      Pages 9-14
    4. Erica D. Wittwer, Wayne T. Nicholson
      Pages 15-22
    5. Michael J. Sikora, Barbara Jericho
      Pages 23-25
  3. Introduction to Drug–Drug Interactions: Brief Review of Cytochrome P450 (CYP450) Enzymes, Uridine 5'-diphospho-glucuronoslytransferases (UGTs), and Transporters

    1. Front Matter
      Pages 27-27
    2. John C. Sanders, Rachel Koll, Randal O. Dull
      Pages 29-32
    3. Benjamin S. Gmelch, Randal O. Dull
      Pages 33-36
    4. Jennifer DeCou, Nathaniel Birgenheier, Randal O. Dull
      Pages 37-40
    5. Danielle Roussel, Emily Hagn, Randal O. Dull
      Pages 41-44
    6. Dustin Coyle, Randal O. Dull
      Pages 45-47
    7. Byron Douglas Fergerson, Crystal B. Wallentine, Randal O. Dull
      Pages 49-51
    8. Barbara Jericho, Alfredo Aguiar, Randal O. Dull
      Pages 53-55
  4. Drug–Drug Interactions: Paradigms and Core Concepts

    1. Front Matter
      Pages 65-65
    2. Dustin Coyle, Erica D. Wittwer, Juraj Sprung
      Pages 67-72
    3. Neil B. Sandson, Michael P. Hutchens, F. Jacob Seagull, Catherine Marcucci
      Pages 73-80
    4. Neil B. Sandson, Catherine Marcucci
      Pages 81-85
    5. Neil B. Sandson, F. Jacob Seagull, Wayne T. Nicholson, Catherine Marcucci
      Pages 87-92
    6. Chad D. Moore, William Hartman, Michael P. Hutchens, Randal O. Dull
      Pages 93-101
    7. Joseph A. Lovely, Stephen Esper, Michael P. Hutchens, Wayne T. Nicholson, Catherine Marcucci
      Pages 103-108
    8. Jessica Voge, David K. Miller
      Pages 109-114
  5. Drug–Drug Interactions Involving Inhalational Anesthetic Agents

    1. Front Matter
      Pages 115-115
    2. Catherine Marcucci
      Pages 117-118
    3. James A. Jernigan, James W. Ibinson
      Pages 119-122
    4. Anthony T. Silipo, Raymond M. Planinsic, Erica D. Wittwer, Juraj Sprung, Wayne T. Nicholson
      Pages 123-128
    5. Jonathan Anson
      Pages 129-132
    6. Brian Gierl, Ferenc E. Gyulai
      Pages 133-136
    7. Jonathon E. Kivela, Toby N. Weingarten, Juraj Sprung
      Pages 137-140
    8. Nikhli Patel, Barbara Jericho, Randal O. Dull
      Pages 141-144
    9. Arun L. Jayaraman, Theresa A. Gelzinis
      Pages 145-148
    10. Phillip Adams, Nashaant N. Rizk
      Pages 149-154
    11. Cornelius B. Groenewald, Juraj Sprung
      Pages 155-160
  6. Drug–Drug Interactions Involving Intravenous Anesthetic Agents

    1. Front Matter
      Pages 161-161
    2. Catherine Marcucci
      Pages 163-164
    3. Helga Komen, Juraj Sprung, Toby N. Weingarten
      Pages 165-168
    4. Charles Galaviz, Randal O. Dull
      Pages 169-172
    5. Ana Maria Manrique, Catherine Marcucci, Kathirvel Subramaniam
      Pages 173-178
    6. Michael P. Hutchens, Edward A. Kahl, Matthias J. Merkel
      Pages 179-182
  7. Drug–Drug Interactions Involving Local Anesthetics

    1. Front Matter
      Pages 183-183
    2. Catherine Marcucci
      Pages 185-186
    3. Joseph J. Yurigan, Todd M. Oravitz
      Pages 187-191
    4. Lauren Partyka, Li Meng
      Pages 193-197
    5. Kitling M. Lum, Kelly N. Stafford
      Pages 199-202
    6. Audra M. Webber, Franklyn P. Cladis
      Pages 203-205
    7. J. Andrew Dziewit, Nabil M. Elkassabany
      Pages 215-218

About this book


The occurrence of deleterious or even fatal drug-drug interactions (DDIs) in the perioperative period is no longer a theoretical concern but a harrowing reality. A Case Approach to Perioperative Drug-Drug Interactions addresses the complex realm of pharmacokinetic drug interactions in an easy-to-read volume that functions as both a comprehensive clinical reference and a casebook.  The book presents a summary of the core concepts of drug interactions; an organized, annotated presentation of the drug interactions most relevant to the perioperative clinician; and approximately 200 case scenarios that highlight specific drug interactions. This book fills a real void in the clinical literature and is invaluable to anesthesiologists and surgeons, and PharmDs, as well as trainees in those specialties; intensive care staff, including physicians, physician assistants, and nurses; and nurse practitioners who staff preoperative evaluation clinics. 


DDIs P450 system anesthesia case drug-drug interactions fatal drug interactions intensive care pain medicine patient safety perioperative medicine quality improvement

Editors and affiliations

  • Catherine Marcucci
    • 1
  • Michael P. Hutchens
    • 2
  • Erica D. Wittwer
    • 3
  • Toby N. Weingarten
    • 3
  • Juraj Sprung
    • 3
  • Wayne T. Nicholson
    • 3
  • Kirk Lalwani
    • 4
  • David G. Metro
    • 5
  • Randal O. Dull
    • 6
  • Christopher E. Swide
    • 7
  • F. Jacob Seagull
    • 8
  • Jeffrey R. Kirsch
    • 9
  • Neil B. Sandson
    • 10
  1. 1.Anesthesia Services DepartmentPhiladelphia Veterans Affairs Med CenterPhiladelphiaUSA
  2. 2.Department of AnesthesiologyOregon Health and Science UniversityPortlandUSA
  3. 3.Department of AnesthesiologyMayo ClinicRochesterUSA
  4. 4.Department of Anesthesiology and Perioperative MedicineOregon Health and Science UniversityPortlandUSA
  5. 5.Department of AnesthesiologyUniversity of Pittsburgh School of Med Liliane S. Kaufmann BuildingPittsburghUSA
  6. 6.Department of AnesthesiologyUniversity of Illinois at ChicagoChicagoUSA
  7. 7.Department of AnesthesiologyPerioperative Medicine, Oregon Health and Science UniversityPortlandUSA
  8. 8.Department of Learning Health SciencesUniversity of Michigan Medical SchoolAnn ArborUSA
  9. 9.Department of Anesthesiology and Perioperative MedicinePortlandUSA
  10. 10.Department of PsychiatryUniversity of Maryland Medical System VA Maryland Health Care SystemBaltimoreUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2015
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-1-4614-7494-4
  • Online ISBN 978-1-4614-7495-1
  • Buy this book on publisher's site