Genetic Variants in Alzheimer's Disease

  • Kevin Morgan
  • Minerva M. Carrasquillo

Table of contents

  1. Front Matter
    Pages i-viii
  2. Minerva M. Carrasquillo, Guojun Bu, Henrietta M. Nielsen
    Pages 7-23
  3. Jenny Lord, Kevin Morgan
    Pages 25-51
  4. Jenny Lord, Kevin Morgan
    Pages 53-76
  5. Jenny Lord, Kevin Morgan
    Pages 77-101
  6. James Turton, Kevin Morgan
    Pages 103-133
  7. James Turton, Kevin Morgan
    Pages 135-158
  8. Kristelle Brown, James Turton, Kevin Morgan
    Pages 159-179
  9. Christopher Medway, Kevin Morgan
    Pages 181-190
  10. Christopher Medway, Anne Braae, Kevin Morgan
    Pages 191-199
  11. Christopher Medway, Kevin Morgan
    Pages 201-208
  12. Minerva M. Carrasquillo, Mariet Allen, Nilüfer Ertekin-Taner
    Pages 209-230
  13. Joanna L. Richens, Bharak Vafadar-Isfahani, Kelly-Ann Vere, Graham Ball, Noor Kalsheker, Robert Rees et al.
    Pages 231-248
  14. Back Matter
    Pages 249-254

About this book

Introduction

Since 2009, a revolution has been witnessed in Alzheimer’s Disease genetics. New genetic links are being discovered at an unprecedented pace and our understanding of the molecular mechanisms of neurodegeneration have taken a quantum leap forward. This book provides a thorough description of the genes that have been implicated in the aetiology of late-onset Alzheimer’s disease (LOAD) based on evidence of genetic association. These “AD susceptibility genes” are described both in their genomic and cellular context, as well as with respect to their known or suspected molecular functions. Although these genes are not sufficient to explain all of the genetic contributions to LOAD, they represent the best replicated set of genes to date. Undoubtedly the list will grow as more advanced genomic approaches towards the identification of novel LOAD genes progresses.

Keywords

Alzheimer's Disease Genetic Variants Genetics Pathways

Editors and affiliations

  • Kevin Morgan
    • 1
  • Minerva M. Carrasquillo
    • 2
  1. 1.Queen's Medical Centre, School of Molecular Medical SciencesUniversity of NottinghamNottinghamUnited Kingdom
  2. 2., Department of NeuroscienceMayo Clinic College of MedicineJacksonvilleUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-7309-1
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-7308-4
  • Online ISBN 978-1-4614-7309-1
  • About this book