Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy

Targeted Therapies to Reverse Resistance

  • Benjamin Bonavida

Part of the Resistance to Targeted Anti-Cancer Therapeutics book series (RTACT, volume 1)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Khyati Kapoor, Hong May Sim, Suresh V. Ambudkar
    Pages 1-34
  3. Ramana V. Tantravahi, Benjamin Hoffman, E. Premkumar Reddy
    Pages 69-88
  4. Srirupa Mukhopadhyay, Parth Malik, Sunil Kumar Arora, Tapan K. Mukherjee
    Pages 89-108
  5. Toshiyuki Matsunaga, Ossama El-Kabbani, Akira Hara
    Pages 109-133
  6. Man-Tzu Wang, Hongmei Jiang, Debasish Boral, Daotai Nie
    Pages 151-161
  7. Elisa Zucca, Emmanuele Crespan, Federica Bertoletti, Miroslava Kissova, Giovanni Maga
    Pages 163-186
  8. Mohamed Saeed, Henry Johannes Greten, Thomas Efferth
    Pages 187-211
  9. Malathy P. V. Shekhar
    Pages 245-258
  10. Back Matter
    Pages 259-260

About this book


Patients with various cancers are treated with conventional chemotherapeutic drugs and the majority responds well to such therapies. However, there is a subset of patients who does not respond initially and another subset who no longer responds to further treatments. Clearly, in those two subsets of patients, the cancer cells exhibit mechanisms of resistance. One of the main challenges facing us to date is to develop new therapies to treat patients with the resistant tumors. The development of new effective therapies will be dependent on delineating the biochemical, molecular, and genetic mechanisms that regulate tumor cell resistance. Such mechanisms have revealed gene products that directly regulate resistance and are targets for therapy. Of interest, several FDA-approved drugs were able to overcome drug resistance and have been successfully used clinically. They have been used as monotherapy or synergized with other therapies for the treatment of resistant tumors.

This volume constitutes a total of twelve selective reviews by pioneer scientists in the field of cancer drug resistance. Specific mechanisms in drug resistance are reviewed and novel approaches are being proposed for therapeutic interventions. This volume is of general interest to scientists, clinicians, health care providers, and students.


ABC Drug transporters HPC1 apoptosis chemoresistance cytotoxics β1 Integrins

Editors and affiliations

  • Benjamin Bonavida
    • 1
  1. 1.Dept. Microbiology, Immunology &, Molecular GeneticsUniversity of California, Los AngelesLos AngelesUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-7069-4
  • Online ISBN 978-1-4614-7070-0
  • Series Print ISSN 2196-5501
  • Series Online ISSN 2196-551X
  • Buy this book on publisher's site