EBNA1 and Epstein-Barr Virus Associated Tumours

  • LoriĀ Frappier

Part of the SpringerBriefs in Cancer Research book series (BRIEFSCANCER, volume 3)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Lori Frappier
    Pages 1-2
  3. Lori Frappier
    Pages 3-18
  4. Lori Frappier
    Pages 19-25
  5. Lori Frappier
    Pages 33-42
  6. Lori Frappier
    Pages 43-43

About this book

Introduction

This SpringerBrief is comprehensive account of the functions and effects of the Epstein-Barr virus (EBV) EBNA1 protein that relate to EBV-associated cancers and evidence for EBNA1 contributions to these cancers.   EBNA1 was the first EBV protein detected and the most critical for EBV latent infection. EBNA1 fulfills multiple functions at EBV genomes which have been described in many (sometimes confusing) reports over the last 28 years. While these were initially thought to be the only roles of EBNA1, many reports in recent years have shown that EBNA1 also directly affects cellular processes in ways that would be expected to contribute to oncogenesis. However, the degree to which EBNA1 promotes cell survival and oncogenesis in various types of human tumours is not entirely clear and a matter of debate. This book offers a current synopsis of EBNA1 functions in EBV latency, including functions in DNA replication, mitotic segregation and transcription. Mechanisms of these EBNA1 functions is also discussed as well as implications for tumourigenesis. In addition, the cellular effects of EBNA1 will be reviewed, including how EBNA1 manipulates specific cellular proteins and relationships to EBV-associated lymphomas and carcinomas.

Keywords

Burkitt's lymphoma EBNA1 PML USP7 gastric carcinoma nasopharyngeal carcinoma

Authors and affiliations

  • LoriĀ Frappier
    • 1
  1. 1.University of TorontoTorontoCanada

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-6886-8
  • Copyright Information The Author(s) 2013
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-6885-1
  • Online ISBN 978-1-4614-6886-8
  • About this book