Molecular Genetics of Pancreatic Cancer

  • Diane M. Simeone
  • Anirban Maitra

Table of contents

  1. Front Matter
    Pages i-v
  2. Marco Dal Molin, Anirban Maitra
    Pages 1-26
  3. Lodewijk A. A. Brosens, G. Johan Offerhaus
    Pages 27-47
  4. Li Jiao, Donghui Li
    Pages 49-74
  5. Helen Court, Mark R. Philips, Dafna Bar-Sagi
    Pages 83-115
  6. Edward Kim, Ethan V. Abel, Arunima Ghosh, Diane M. Simeone
    Pages 117-144
  7. Filip Bednar, Marina Pasca di Magliano
    Pages 145-170
  8. Christine A. Iacobuzio-Donahue
    Pages 171-184
  9. Michael Ayars, Michael Goggins
    Pages 185-207
  10. Back Matter
    Pages 229-235

About this book

Introduction

Pancreatic cancer is a formidable disease, and advances in early detection and improved therapeutics have been slow to come forth. With new advances in molecular genetics in the field of pancreatic tumorigenesis, it is an opportune time to use these recent discoveries to enhance our understanding of pancreatic cancer biology and to improve outcomes in patients.  In this volume, leading experts in the field shed light on these findings describing the mutational landscape of pancreatic cancer, including new inroads into our understanding of familial pancreatic cancer, epidemiology, the biology of K-ras signaling, and the emerging contribution of epigenetic alterations to disease initiation and progression. The distinctive pancreatic cancer-stroma ecosystem as determined by the dynamic interplay of inflammation, hallmark mutations, EMT, and cancer stem cells is described, and implications of these interactions in the context of development of novel, personalized therapeutic options are explored.

Keywords

K-ras signaling Pancreatic Ductal Adenocarcinoma Wnt pathways tumor-suppressor genes tumorigenesis

Editors and affiliations

  • Diane M. Simeone
    • 1
  • Anirban Maitra
    • 2
  1. 1.MED CTR ROOM 2922D, TCUniversity of MichiganAnn ArborUSA
  2. 2.CRB 2/STE 345Johns Hopkins UniversityBaltimoreUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-6549-2
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-6548-5
  • Online ISBN 978-1-4614-6549-2
  • About this book