Stem Cells and Prostate Cancer

  • Scott D. Cramer

Table of contents

  1. Front Matter
    Pages i-vii
  2. Gail S. Prins, Wen-Yang Hu
    Pages 1-20
  3. Andrew S. Goldstein, Owen N. Witte
    Pages 21-36
  4. Xin Chen, Dean G. Tang
    Pages 37-49
  5. David Moscatelli, E. Lynette Wilson
    Pages 91-109
  6. Gail P. Risbridger, Renea A. Taylor
    Pages 111-125
  7. Molishree U. Joshi, Courtney K. von Bergen, Scott D. Cramer
    Pages 127-148
  8. Lindsey Ulkus, Min Wu, Scott D. Cramer
    Pages 149-173
  9. Back Matter
    Pages 175-182

About this book

Introduction

Recent evidence demonstrates that normal prostate tissue contains stem cells.  There is also accumulating evidence that prostate cancer contains a population of cells with stem cell-like characteristics referred to as cancer stem cells, or tumor initiating cells.  Both the normal prostate stem cell and cancer stem cell populations have important implications for the generation, therapeutic targeting, and prevention of prostate cancer.  This book will explore the role of stem cells in normal prostate development and prostate cancer, methods for isolation and characterization of normal prostate stem cells and prostate tumor initiating cells, the functional relationship between normal stem cells and prostate tumor initiating cells, the relationship of prostate cancer genetics and self-renewal and differentiation, the prostate stem cell as a target for therapeutics and prevention, and the utility of stem cells for prostate cancer models.  This book synthesizes these concepts and more into a single volume accessible to basic and translational researchers in prostate cancer and beyond.

Keywords

Tumor-initiating cells androgen receptors microRNAs p57 tumor suppressors

Editors and affiliations

  • Scott D. Cramer
    • 1
  1. 1.Anschutz Medical CampusUniversity of ColoradoAuroraUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-6498-3
  • Copyright Information Springer Science+Business Media, LLC 2013
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-6497-6
  • Online ISBN 978-1-4614-6498-3
  • About this book