Pharmacoresistance in Epilepsy

From Genes and Molecules to Promising Therapies

  • Luisa Rocha
  • Esper A. Cavalheiro

Table of contents

  1. Front Matter
    Pages i-xii
  2. Francisco Rubio-Donnadieu
    Pages 1-9
  3. Iris E. Martínez-Juárez, Laura Elena Hernández-Vanegas, Nayelli Rodríguez y Rodríguez, Jorge Alfredo León-Aldana, Antonio V. Delgado-Escueta
    Pages 11-25
  4. Alberto Lazarowski, Liliana Czornyj
    Pages 47-57
  5. Monica E. Ureña-Guerrero, Alfredo I. Feria-Velasco, Graciela Gudiño-Cabrera, Antoni Camins Espuny, Carlos Beas-Zárate
    Pages 59-76
  6. Martha Rivera-Cervantes, Alfredo I. Feria-Velasco, Felix Junyent, Antoni Camins Espuny, Carlos Beas-Zárate
    Pages 77-97
  7. Carme Auladell, Felix Junyent, Aurelio Vazquez de la Torre, Maria Luisa de Lemos, Mercè Pallàs, Ester Verdaguer Cardona et al.
    Pages 99-113
  8. Maria José da Silva Fernandes, Rebeca Padrão Amorim, Jose Eduardo Marques Carneiro, Michelle Gasparetti Leão Araújo, Daniele Suzete Persike
    Pages 115-126
  9. Sandra Orozco-Suárez, David Escalante-Santiago, Iris Angélica Feria-Romero, Monica E. Ureña-Guerrero, Luisa Rocha, Mario A. Alonso-Vanegas et al.
    Pages 127-147
  10. Lourdes Lorigados Pedre, Lilia Maria Morales Chacón, Sandra Orozco-Suárez, Luisa Rocha
    Pages 149-168
  11. Pietro Fagiolino, Marta Vázquez, Sandra Orozco-Suárez, Cecilia Maldonado, Silvana Alvariza, Iris Angélica Feria-Romero et al.
    Pages 169-184
  12. Cecilia Zavala-Tecuapetla, Luisa Rocha
    Pages 185-197
  13. Carla A. Scorza, Esper A. Cavalheiro
    Pages 199-205
  14. Mario A. Alonso-Vanegas
    Pages 233-252
  15. Ana Luisa Velasco, Francisco Velasco
    Pages 253-263
  16. Lilia Maria Morales Chacón, Lázaro Gómez Fernández, Otto Trápaga Quincoses, Genco Marcio Estrada Vinajera, Lourdes Lorigados Pedre, Marilyn Zaldivar Bermudes et al.
    Pages 265-289
  17. Ricardo Mario Arida, Fulvio Alexandre Scorza
    Pages 307-320
  18. Back Matter
    Pages 321-329

About this book


Although more than 10 new antiepileptic drugs have been developed in the past decade, epilepsy remains resistant to drug therapy in about one-third of patients, many of whom struggle with the disease their entire lives. Managing these patients is a challenge and requires a structured multidisciplinary approach. The book includes chapters on all issues related to pharmacoresistance in epilepsy, and describes recent developments in the pathogenesis and treatment of this disorder. It addresses abnormalities in inhibitory mechanisms, epilepsy-related changes to the immune system, development of pharmacoresistance caused by chronic exposure to antiepileptic drugs, and novel therapeutic strategies for preventing or slowing down the progression of the disease.

Clinicians and basic scientists alike will find up-to-date information on the development of pharmacoresistance, as well as reviews of mechanisms associated with epilepsy that may help them consider novel strategies for preventing the development of pharmacoresistance in the first place. The book also features information on new therapeutic strategies for control of epilepsy, such as transcutaneous electrical stimulation and virtual screening of new antiepileptic drugs. Pharmacoresistance in Epilepsy: From Genes and Molecules to Promising Therapies is useful to anyone working in the field, whether they’re studying epilepsy in the lab or treating it in a doctor’s office.


epilepsy neurotoxicity pharmacoresistance therapeutic strategies in epilepsy

Editors and affiliations

  • Luisa Rocha
    • 1
  • Esper A. Cavalheiro
    • 2
  1. 1., Pharmacobiology DepartmentCenter for Research and Advanced StudiesMexico CityMexico
  2. 2., Disciplina de Neurologia ExperimentalUNIFESP/EPMSão PauloBrazil

Bibliographic information