The Hippo Signaling Pathway and Cancer

  • Moshe Oren
  • Yael Aylon

Table of contents

  1. Front Matter
    Pages i-vi
  2. Moshe Oren, Yael Aylon
    Pages 1-8
  3. Up-stream Components of Hippo Signaling

    1. Front Matter
      Pages 9-9
    2. Chunling Yi, Joseph Kissil
      Pages 11-25
    3. Julien Fitamant, Dawang Zhou, Fan Mou, Laura Regué Barrufet, Nabeel Bardeesy, Joseph Avruch
      Pages 27-49
  4. YAP and TAZ

    1. Front Matter
      Pages 51-51
    2. Fa-Xing Yu, Bin Zhao, Kun-Liang Guan
      Pages 71-87
    3. Stefano Piccolo, Michelangelo Cordenonsi
      Pages 89-113
  5. Apoptosis and Hippo Signaling

    1. Front Matter
      Pages 115-115
    2. Garth Hamilton, Eric O’Neill
      Pages 117-145
    3. Sara Donzelli, Sabrina Strano, Giovanni Blandino
      Pages 147-172
    4. Nina Reuven, Yosef Shaul
      Pages 173-195
  6. Cell Cycle and Hippo Signaling

    1. Front Matter
      Pages 197-197
    2. Norikazu Yabuta, Hiroshi Nojima
      Pages 199-221
  7. Mouse Models

    1. Front Matter
      Pages 223-223
    2. Min-Chul Kim, Tae-Shin Kim, Tackhoon Kim, Dae-Sik Lim
      Pages 225-247
    3. Kriti Shrestha, Fernando D. Camargo
      Pages 265-279
    4. Randy L. Johnson
      Pages 281-291

About this book

Introduction

The Hippo signaling pathway is rapidly gaining recognition as an important player in organ size control and tumorgenesis. This volume presents virtually all aspects of tumor biology because members of the Hippo Pathway have been associated with numerous well-established cell signaling pathways, just to name a few; Rho, Wnt, TGFbeta and p53. Hippo signaling is not solely involved in regulating “classic” tumor characteristics such as cell proliferation, survival and growth, but is also diversely involved in cell-autonomous and non-cell-autonomous differentiation, migration and organ size control.

With the multitude of signaling events mediated by the Hippo pathway and the vastly different functions that it plays, it is evident that these tumor suppressors are unique governors of cellular homeostasis. This timely volume gathers wide-ranging and burgeoning information on the Hippo pathway and its role in cancer into an accessible format of a single book.With the multitude of signaling events mediated by the Hippo pathway and the vastly different functions that it plays, it is evident that these tumor suppressors are unique governors of cellular homeostasis. This timely volume gathers wide-ranging and burgeoning information on the Hippo pathway and its role in cancer into an accessible format of a single book.

Keywords

TAZ transcription YAP1 angiomotin hippo-yap signaling p73

Editors and affiliations

  • Moshe Oren
    • 1
  • Yael Aylon
    • 2
  1. 1., Department of Molecular Cell BiologyWeizmann Institute of ScienceRehovotIsrael
  2. 2., Department of Molecular Cell BiologyWeizmann Institute of ScienceRehovotIsrael

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-6220-0
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-6219-4
  • Online ISBN 978-1-4614-6220-0
  • About this book