The New Paradigm of Immunity to Tuberculosis

  • Maziar Divangahi

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 783)

Table of contents

  1. Front Matter
    Pages i-vi
  2. G. J. Fox, D. Menzies
    Pages 1-32
  3. Tania Di Pietrantonio, Erwin Schurr
    Pages 33-44
  4. Marcel A. Behr
    Pages 81-91
  5. Ryan P. Larson, Shahin Shafiani, Kevin B. Urdahl
    Pages 165-180
  6. Ildiko Van Rhijn, Dalam Ly, D. Branch Moody
    Pages 181-197
  7. Pooja Arora, Erin L. Foster, Steven A. Porcelli
    Pages 199-223
  8. Lee Kozakiewicz, Jiayao Phuah, JoAnne Flynn, John Chan
    Pages 225-250
  9. Back Matter
    Pages 279-292

About this book

Introduction

This book illustrates the intimate relationship between alveolar macrophages and Mycobacterium tuberculosis (M.tb.), and the former’s role in both innate and adaptive immunity against M.tb. It covers research done over the last decade. It also explores the role of macrophage death following infection with M.tb. in determining whether successful immunity is stimulated, or whether clinical disease develops; furthermore, the function of host lipid mediators in macrophage death modality are addressed.

The book also illustrates how the balance between prostaglandins and lipoxins determines whether infected macrophages undergo apoptosis or necrosis, which is the ultimate factor in the outcome of infection.

Finally, it is a synthesis of the authors’ recent studies and the studies of others to offer a new understanding of immunity to tuberculosis.

Keywords

Cell death program Host-pathogen interaction Innate and adaptive immunity Mycobacteria Tuberculosis

Editors and affiliations

  • Maziar Divangahi
    • 1
  1. 1.McGill UniversityMontrealCanada

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-6111-1
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-6110-4
  • Online ISBN 978-1-4614-6111-1
  • Series Print ISSN 0065-2598
  • About this book