Pathobiology of Cancer Regimen-Related Toxicities

  • Stephen T. Sonis
  • Dorothy M. Keefe

Table of contents

  1. Front Matter
    Pages i-x
  2. General Concepts Affecting Regimen-Related Toxicities

    1. Front Matter
      Pages 1-1
    2. Linda S. Elting, Yu-Chia Chang, Pratibha Parelkar
      Pages 3-17
    3. Edouard I. Azzam, Sonia M. de Toledo, Andrew L. Harris, Vladimir Ivanov, Hongning Zhou, Sally A. Amundson et al.
      Pages 35-61
    4. Gregory Lyng, Richard Logan, Maria Mancini
      Pages 75-95
  3. The Pathobiology of Specific Toxicities

    1. Front Matter
      Pages 97-97
    2. Pernille H. Hansen, Jesper Palshof, Jørn Herrstedt
      Pages 99-119
    3. Noor Al-Dasooqi, Dorothy M. Keefe, Dorothy M. Keefe, Stephen T. Sonis
      Pages 121-146
    4. Yevgeniy Balagula, Mario E. Lacouture
      Pages 147-166
    5. Lynne A. Murray, Matthew A. Sleeman
      Pages 167-186
    6. David C. Dale
      Pages 187-205
    7. Elizabeth K. Joseph
      Pages 207-215
    8. Jonathan A. Zombeck
      Pages 217-232
    9. Ana P. Cotrim, Changyu Zheng, Bruce J. Baum
      Pages 233-248
    10. Caterina Musolino, Alessandro Allegra
      Pages 249-282
  4. Conclusions and Therapeutic Opportunities

    1. Front Matter
      Pages 283-283
    2. Stephen T. Sonis, Stephen T. Sonis, Stephen T. Sonis, Dorothy M. Keefe, Dorothy M. Keefe, Dorothy M. Keefe et al.
      Pages 285-286
  5. Back Matter
    Pages 287-292

About this book


Toxicities have been consistent undesirable companions of every form of radiation and drug cancer treatment regimens.  In addition to the potential for toxicities to devastate patients’ quality of life, they generate huge incremental financial costs, and sap patients’ ability to tolerate definitive cancer therapy.   And every new drug or biological has come with new side effects.   Historically, regimen-related toxicities were viewed as the inevitable cost of treating cancer.  But this may be about to change.

Discoveries in the past dozen years have painted a new picture of the pathobiology of almost all regimen-related toxicities.  The mechanistic complexities that underlie radiation- and chemotherapy-induced tissue injury or systemic symptoms have been pieced together in an incremental sequence which now provides multiple targets for effective toxicity interventions.

This book brings together, for the first time in a single volume, the most current information regarding both general principles guiding current thinking about the pathogenesis of regimen-related toxicities and the specific biological underpinnings of the most common side effects of cancer therapy.  The contents provide information that is essential to clinicians and basic and translational scientists interested in cancer therapy and its toxicities.


Bioinformatics Cancer Research Cancer Research Pharmacology Toxicology

Editors and affiliations

  • Stephen T. Sonis
    • 1
  • Dorothy M. Keefe
    • 2
  1. 1.Brigham and Women’s HospitalBostonUSA
  2. 2.Royal Adelaide HospitalAdelaideAustralia

Bibliographic information