© 2013

Systems Biology of Tuberculosis

  • Johnjoe McFadden
  • Dany J.V. Beste
  • Andrzej M. Kierzek

Table of contents

  1. Front Matter
    Pages i-xv
  2. Neema Jamshidi, Aarash Bordbar, Bernhard Palsson
    Pages 1-19
  3. Samik Ghosh, Yukiko Matsuoka, Yoshiyuki Asai, Hiroaki Kitano, Anshu Bhardwaj, Vinod Scaria et al.
    Pages 21-35
  4. Kanury V. S. Rao, Dhiraj Kumar, Shekhar C. Mande
    Pages 37-54
  5. Dany J. V. Beste, Johnjoe McFadden
    Pages 55-78
  6. Simon J. Waddell, Axel von Kamp, Steffen Klamt, Olivier Neyrolles
    Pages 107-126
  7. Mohammad Fallahi-Sichani, Simeone Marino, JoAnne L. Flynn, Jennifer J. Linderman, Denise E. Kirschner
    Pages 127-155
  8. Andrea Rocco, Andrzej Kierzek, Johnjoe McFadden
    Pages 157-177
  9. Nagasuma Chandra
    Pages 179-192
  10. Richard Pine, Yuri Bushkin, Maria Laura Gennaro
    Pages 193-219
  11. Back Matter
    Pages 221-226

About this book


Tuberculosis remains one of the world’s biggest killers responsible for more than a million deaths each year. New drugs and new vaccines are urgently needed to tackle the disease. This book describes the application of this century’s first new science, systems biology, to the study of tuberculosis. After introducing the basic principles of systems biology, successive chapters describe how systems-based approaches provide new insights into gene regulation, metabolism, protein-protein interaction, host-pathogen interactions, the immune response, persistence, drug treatment and diagnosis of tuberculosis. This book will be an invaluable aid to anyone interested in exploring how the latest science is helping us to understand this ancient disease.

Editors and affiliations

  • Johnjoe McFadden
    • 1
  • Dany J.V. Beste
    • 2
  • Andrzej M. Kierzek
    • 3
  1. 1.Microbial and Cellular SciencesUniversity of SurreyGuildfordUnited Kingdom
  2. 2.School of Biomedical and Molecular ScienUniversity of SurreyGuildfordUnited Kingdom
  3. 3.Faculty of Health and Medical SciencesUniversity of SurreyGuildfordUnited Kingdom

Bibliographic information