Microdialysis in Drug Development

  • Markus Müller

Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 4)

Table of contents

  1. Front Matter
    Pages i-xi
  2. General Aspects

    1. Front Matter
      Pages 1-1
    2. Justin C. Cooley, Michael W. Ducey, Anne R. Regel, Pradyot Nandi, Susan M. Lunte, Craig E. Lunte
      Pages 35-66
    3. Chinmay Shukla, Jing Li, Robert Lionberger, Edward D. Bashaw
      Pages 67-80
  3. Specific Topics

    1. Front Matter
      Pages 81-81
    2. Markus Zeitlinger, Sandrine Marchand, William Couet, Aline Barth, Hartmut Derendorf
      Pages 103-126
    3. Eva Benfeldt
      Pages 127-142
    4. Martin Brunner
      Pages 179-196
    5. Mitesh R. Patel, Nanda K. Mandava, Ashim K. Mitra
      Pages 197-222
    6. Per-Anders Jansson
      Pages 223-241
    7. Geraldine F. Clough, Julie A. Stenken, Martin K. Church
      Pages 243-268
    8. Thomas Pieber, Thomas Birngruber, Manfred Bodenlenz, Christian Höfferer, Selma Mautner, Katrin Tiffner et al.
      Pages 283-302
    9. Robert Sauermann, Markus Zeitlinger
      Pages 303-333
  4. Back Matter
    Pages 335-338

About this book

Introduction

In vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical reach. Today, a direct measurement of target site concentrations is possible by employing microdialysis or complementary approaches such as imaging technologies. Microdialysis, initially conceived in the 1970ies, has become a standard tool in drug development. This comprehensive overview of current microdialysis technology covers general and disease-specific aspects of microdialysis by international experts in the field. It provides useful information for colleagues in academia and industry who are interested PK-PD aspects of drug development.

Keywords

Development Drug Microdialysis Pharmaceutical

Editors and affiliations

  • Markus Müller
    • 1
  1. 1.Allgemeines Krankenhaus, Department of Clinical PharmacologyMedical University ViennaViennaAustria

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-4815-0
  • Copyright Information American Association of Pharmaceutical Scientists 2013
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-4814-3
  • Online ISBN 978-1-4614-4815-0
  • Series Print ISSN 2210-7371
  • Series Online ISSN 2210-738X
  • About this book