© 2013

RNA Interference from Biology to Therapeutics

  • Kenneth A. Howard

Part of the Advances in Delivery Science and Technology book series (ADST)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Jesper B. Bramsen, Thomas B. Hansen
    Pages 1-29
  3. Scott D. Rose, Mark A. Behlke
    Pages 31-56
  4. Morten Østergaard Andersen, Philipp Dillschneider, Jørgen Kjems
    Pages 57-78
  5. Yu Zhu, Jing Li, David Oupický
    Pages 79-95
  6. Borja Ballarín González, Ebbe Bech Nielsen, Troels Bo Thomsen, Kenneth A. Howard
    Pages 97-125
  7. Frederico Pittella, Kazunori Kataoka
    Pages 161-184
  8. Samira Lakhal, Samir El Andaloussi, Aisling J. O’Loughlin, Jinghuan Li, Matthew M. J. Wood
    Pages 185-205
  9. Jiehua Zhou, John J. Rossi
    Pages 207-220
  10. Ben Berkhout, Julia J. M. Eekels
    Pages 221-242
  11. Karina D. Sørensen, Marie S. Ostenfeld, Dennis K. Jeppesen, Helle Kristensen, Christa Haldrup, Torben F. Ørntoft
    Pages 259-298
  12. Nobuyoshi Kosaka, Fumitaka Takeshita, Yusuke Yoshioka, Takahiro Ochiya
    Pages 299-314
  13. Amy R. Simon, Verena Karsten, Rachel Meyers, Jeff Cehelsky, Jared Gollob, Akshay Vaishnaw et al.
    Pages 315-328
  14. Back Matter
    Pages 329-337

About this book


The Nobel Prize winning discovery that small interfering RNA can be utilised to control cellular gene expression has propelled the field of RNA interference (RNAi) to the forefront of biomedical science as a potential molecular medicine set to revolutionalise disease treatment.  

Harnessing the molecular mechanisms of RNAi and development of delivery technologies is crucial for its transformation into a therapeutic modality, this dependency is the focus of “RNA Interference from Biology to Therapeutics” that gives a comprehensive overview of RNAi biology and state-of-the-art delivery methods relevant to clinical translation of RNAi therapeutics.

Key players and shapers in the fields of RNAi and delivery science have been assembled in a single volume to produce a truly unique interdisciplinary text, making it a “must-read” for both students and experts in, and at the interface of, RNAi, pharmaceutical science and medicine. An attractive feature is the “future perspectives” section within each chapter that allows global leaders the opportunity to express their views on the direction the field is moving. Topics covered in the book include miRNA biology and therapeutic exploitation, exosome delivery and clinical translation.

“RNA Interference from Biology to Therapeutics” is an up-to-the-minute, highly informative and invaluable text for those actively involved or interested in this fascinating and high-impact field.


Gene Silencing MicroRNA Nanomedicine Nanoparticles RNA Interference (RNAi) RNAi Clinical Trials RNAi Therapeutics Small interfering RNA (siRNA) siRNA Delivery

Editors and affiliations

  • Kenneth A. Howard
    • 1
  1. 1.Interdisciplinary Nanoscience CenterAarhus UniversityAarhusDenmark

About the editors

Kenneth Alan Howard is an Associate Professor and Group Leader at the Department of Molecular Biology at the Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Denmark. His team is based in a highly interdisciplinary setting with research and teaching activities focused on advanced drug delivery, nanomedicine, RNA interference, and inflammation. Dr Howard is CEO of an Aarhus University spin-out company that provides delivery solutions for RNA interference-based therapeutics. Kenneth Alan Howard received a PhD in Pharmaceutical Science from the University of Nottingham, UK in 1995, and has held postdoctoral positions at the CRC Institute for Cancer Studies, University of Birmingham, UK and the School of Pharmacy, University of London. Dr Howard is an active member of the Controlled Release Society serving on the Board of Scientific Advisors (chair), Nominations Committee and organizer of a CRS Educational workshop “RNA Interference Biology and Therapeutics”.   

Bibliographic information