Table of contents

  1. Front Matter
    Pages i-viii
  2. Anderson T. Wang, Peter J. McHugh, John A. Hartley
    Pages 1-23
  3. Bernard Salles, Patrick Calsou, Gladys Mirey
    Pages 25-44
  4. Jennifer J. Hu, Joseph de la Garza, Sathish K. Srinivasan, Ann Alyssa Kurian, Feng Gong
    Pages 129-142
  5. Andrew Y. Shuen, Jorge S. Reis-Filho, William D. Foulkes
    Pages 143-155
  6. L. Amrein, D. Davidson, R. Aloyz, L. Panasci
    Pages 157-166
  7. Jana Krietsch, Michèle Rouleau, Michel Lebel, Guy Poirier, Jean-Yves Masson
    Pages 167-186
  8. Dindial Ramotar, Mustapha Aouida
    Pages 187-209
  9. Fiona K. Middleton, Nicola J. Curtin
    Pages 211-228
  10. Raina A. Tamakawa, Helen B. Fleisig, Judy M. Y. Wong
    Pages 229-279
  11. Alexander V. Mazin, Olga M. Mazina
    Pages 281-302
  12. Back Matter
    Pages 303-312

About this book

Introduction

This book deals with the emerging role of various DNA repair proteins and the regulatory elements which are implicated in cancer therapy such as DNA cross-linking agents, radiotherapy and bleomycin.  The DNA repair genes discussed include those involved in BRCA/Rad51-related homologous recombinational repair, DNA-PK related nonhomologous endjoining and the nucleotide excision repair gene, ERCC1.  Moreover, the role of regulatory genes such as PARP, ATR, telomerase, growth factor receptors and downstream kinase signalling  is examined.

Keywords

DNA damage DNA-PK ERCC1 chemotherapeutic drugs telomeres

Editors and affiliations

  • Lawrence Panasci
    • 1
  • Raquel Aloyz
    • 2
  • Moulay Alaoui-Jamali
    • 3
  1. 1.Jewish General HospitalMontrealCanada
  2. 2., Department of OncologyMcGill UniversityMontrealCanada
  3. 3.McGill University, Department of Medicine and OncologyFaculty of MedicineMontrealCanada

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-4741-2
  • Copyright Information Springer Science+Business Media, LLC 2013
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine
  • Print ISBN 978-1-4614-4740-5
  • Online ISBN 978-1-4614-4741-2
  • About this book