Advances in Biology and Therapy of Multiple Myeloma

Volume 1: Basic Science

  • Nikhil C. Munshi
  • Kenneth C. Anderson

Table of contents

  1. Front Matter
    Pages i-x
  2. Myeloma Molecular Pathways and Cell Signaling

    1. Front Matter
      Pages 1-1
    2. Saad Usmani, B. Barlogie, J. D. Shaughnessy Jr.
      Pages 41-63
    3. Jérôme Moreaux, Caroline Bret, Karène Mahtouk, Anne-Catherine Sprynski, Dirk Hose, Bernard Klein
      Pages 65-84
    4. Mariateresa Fulciniti, Daniel R. Carrasco
      Pages 85-95
    5. Joseph Gera, Alan Lichtenstein
      Pages 97-116
    6. Erik A. Nelson, Sarah R. Walker, David A. Frank
      Pages 117-138
  3. Myeloma Microenvironment

    1. Front Matter
      Pages 139-139
    2. Deborah L. Galson, Sonia D’Souza, G. David Roodman
      Pages 169-185
    3. Stephen A. Mihalcik, Diane F. Jelinek
      Pages 187-202
    4. Sonia Vallet, Noopur Raje
      Pages 203-214
    5. Giada Bianchi, Irene M. Ghobrial
      Pages 215-239
    6. Elke De Bruyne, Ken Maes, Sarah Deleu, Els Van Valckenborgh, Eline Menu, Isabelle Vande Broek et al.
      Pages 255-282
    7. Klaus Podar, Kenneth C. Anderson
      Pages 283-299
    8. Eric Sanchez, Haiming Chen, James R. Berenson
      Pages 301-312
  4. Back Matter
    Pages 313-319

About this book


Despite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in multiple myeloma focusing on the development of molecularly-based novel targeted single-agent and combination therapies has great promise to achieve high frequency and durable responses in the majority of patients.


This volume will focus on biology of multiple myeloma, especially on oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies. The book will present newer developments, providing an emphasis on basic science, as well as its significant clinical impact.


Kahler's disease MGUS cancer hematological malignancy plasma cell myeloma plasma cells

Editors and affiliations

  • Nikhil C. Munshi
    • 1
  • Kenneth C. Anderson
    • 2
  1. 1.Dana-Farber Cancer InstituteHarvard Medical SchoolBostonUSA
  2. 2.Dana-Farber Cancer Institute, Dept. Medical OncologyHarvard Medical SchoolBostonUSA

Bibliographic information