Natural Products and Cancer Drug Discovery

  • Frank E. Koehn

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Natural Product Drugs and Cancer Therapeutics

  3. Advances in Natural Product Cancer Drug Discovery

    1. Front Matter
      Pages 121-121
    2. Christian P. Mang, Lars Ole Haustedt
      Pages 123-173
    3. Claudia Eva-Maria Unsin, Scott R. Rajski, Ben Shen
      Pages 175-191
    4. Lisa M. Leone, Susan C. Roberts
      Pages 193-211
  4. Back Matter
    Pages 239-244

About this book

Introduction

Natural products- compounds derived from plants, microbes and marine organisms, have been an unsurpassed source of cancer drugs in the modern era of drug discovery.  The historical record is strong, but what is the current impact of natural  products in the discovery and development of cancer drugs, and importantly what are the prospects for natural products to be a valuable source of  future agents? 

This volume attempts to address this question through a series of chapters authored by leading researchers in the field which effectively provide an in-depth view of several high impact areas of natural products cancer research. The volume begins with a focused analysis and rationale for the clinical success  of current natural product anti-cancer drugs. The following chapters then describe new natural product based drugs in three rapidly evolving target classes and modalities- agents which target tumor vasculature, inhibitors of histone deacetylase and other histone modifying enzymes, and  antibody drug conjugates.  Subsequent chapters examine the central role of natural product chemical scaffolds in the genesis of new anti-cancer therapeutics- first via the powerful application of chemical synthesis, and then through the  rapidly emerging fields of biosynthetic engineering and plant cell culture.  The volume concludes with an assessment of the critical role that natural products continue to play in the search for new cancer drug targets.  As the reader makes his or her way through the volume it may become clear that there is strong evidence that natural products will continue to exert a profound positive impact on cancer drug discovery.

Keywords

HDAC inhibitors Natural Products and Cancer Drug Discovery cancer therapeutics discodermolide natural product cytotoxins

Editors and affiliations

  • Frank E. Koehn
    • 1
  1. 1., Natural Products/World Wide Medicinal ChPfizer IncGrotonUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-4654-5
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine
  • Print ISBN 978-1-4614-4653-8
  • Online ISBN 978-1-4614-4654-5
  • About this book