Mitochondria and Their Role in Cardiovascular Disease

  • José Marín-García

Table of contents

  1. Front Matter
    Pages i-xix
  2. General Principles of Mitochondria and the Heart

    1. Front Matter
      Pages 1-1
    2. José Marín-García
      Pages 3-11
    3. José Marín-García
      Pages 29-57
    4. José Marín-García
      Pages 59-97
    5. José Marín-García
      Pages 99-121
  3. Heart Mitochondria Signal Transduction: Stem Cells

    1. Front Matter
      Pages 145-145
    2. José Marín-García
      Pages 183-201
  4. Stress and Cell Death

    1. Front Matter
      Pages 203-203
    2. José Marín-García
      Pages 205-223
    3. José Marín-García
      Pages 225-241
  5. Mitochondria in Pediatric Cardiology

    1. Front Matter
      Pages 243-243
    2. José Marín-García
      Pages 245-270
  6. The Aging Heart and Mitochondria

    1. Front Matter
      Pages 271-271
    2. José Marín-García
      Pages 273-291
  7. Mitochondria in Atherosclerosis, Hypertension and Ischemia

    1. Front Matter
      Pages 293-293

About this book

Introduction

Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically. We now know that these organelles play a critical role in the normal and in the damaged heart. Written by Dr. José Marín-García, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Disease brings readers up- to-date on the many significant advances in the field of mitochondrial cardiovascular medicine.  The book begins with a general introduction to mitochondria, followed by laboratory methods to study the structure and function of the organelle, regulation of replication and biogenesis, and the mechanisms and functional consequences of mitophagia and mitochondrial dynamics. Subsequent chapters deal with mitochondrial oxidative stress and the role that the organelle plays in cell signaling and cell death. Discussions will be undertaken on the biochemistry of mitochondrial cell signaling, including the nature of the proteins engaged in these processes, many of them only recently discovered. Later chapters examine the role of mitochondria and mitochondrial abnormalities in cardiovascular diseases, including their diagnosis, therapeutic options currently available, animal models of mitochondrial disease, and new frontiers in mitochondria cardiovascular medicine, including areas of research that are relatively new or developing, such as proteomics, next generation sequencing, and systems biology.


Keywords

Cardiac Disease Cardiovascular Disease Genetics Mitochondria Mitochondrial Medicine Molecular Biology

Authors and affiliations

  • José Marín-García
    • 1
  1. 1.Neuromuscular InstituteThe Molecular Cardiology andHighland ParkUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-4599-9
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Springer, Boston, MA
  • eBook Packages Medicine
  • Print ISBN 978-1-4614-4598-2
  • Online ISBN 978-1-4614-4599-9
  • About this book