The Brain-Dead Organ Donor

Pathophysiology and Management

  • Dimitri Novitzky
  • David K C Cooper

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Dimitri Novitzky, David K. C. Cooper
    Pages 1-6
  3. Félix Bacigalupo, Daniela A. Huerta Fernández
    Pages 7-11
  4. Curtis M. Keller, Boris Chulpayev, Michael Hoffmann
    Pages 13-19
  5. Ricky T. Munoz, Mark D. Fox
    Pages 21-35
  6. Mark D. Fox, Ricky T. Munoz
    Pages 37-53
  7. Bernhard Floerchinger, Nicholas L. Tilney, Stefan G. Tullius
    Pages 55-64
  8. Dimitri Novitzky, Winston N. Wicomb, David K. C. Cooper
    Pages 65-90
  9. Anne Barklin, Christine Lodberg Hvas, Else Toennesen
    Pages 107-119
  10. Marc A. Seelen, Henri G. D. Leuvenink, Rutger J. Ploeg
    Pages 139-145
  11. Kadiyala V. Ravindra, Keri E. Lunsford, Paul C. Kuo
    Pages 147-154
  12. Nicole M. Theodoropoulos, Michael G. Ison
    Pages 155-176
  13. Michael A. Nalesnik, Ron Shapiro, Michael G. Ison
    Pages 177-189
  14. Dimitri Novitzky, Burcin Ekser, David K. C. Cooper
    Pages 191-207
  15. Peter S. Macdonald, Anders E. M. Aneman, Deepak Bhonagiri, Daryl A. Jones, Gerry O’Callaghan, Helen I. Opdam et al.
    Pages 237-249
  16. Michael J. Anstadt, Paul C. Kuo, Kadiyala V. Ravindra
    Pages 263-281
  17. Winston N. Wicomb, David K. C. Cooper
    Pages 283-288
  18. Coney Bae, Anthony Watkins, Scot D. Henry, James V. Guarrera
    Pages 289-298
  19. Henri G. D. Leuvenink, Marc A. Seelen, Rutger J. Ploeg
    Pages 299-310
  20. Jonathan C. Yeung, Marcelo Cypel, Shaf Keshavjee
    Pages 311-320
  21. Dimitri Novitzky, David K. C. Cooper
    Pages 321-331
  22. Back Matter
    Pages 355-368

About this book


Addressing all aspects of brain death and thoroughly detailing how a potential organ donor should be maintained to ensure maximum use of the organs and cells, The Brain-Dead Organ Donor: Pathophysiology and Management is a landmark addition to the literature.  This first-of-its-kind, multidisciplinary volume will be of interest to a large section of the medical community. The first section of the book reviews the historical, medical, legal, and ethical aspects of brain death.  That is followed by two chapters on the pathophysiology of brain death as investigated in small and large animal models.  This includes a review of the many hormonal changes, including the neuroendocrine- adrenergic ‘storm’, that takes place during and following the induction of brain death, and how they impact metabolism.  The next section of the book reviews various effects of brain death, namely its impact on thyroid function, the inflammatory response that develops, and  those relating to innate immunity. The chapters relating to assessment and management of potential organ donors will be of interest to a very large group of transplant surgeons and physicians as well as critical care and neurocritical care physicians and nurses. Neurologists, endocrinologists, neurosurgeons, and pathologists will also be interested, especially in the more basic science sections on various aspects of brain-death and hormonal therapy. Organ procurement organizations and transplant coordinators worldwide will also be interested in this title. Other chapters will be of interest to medical historians, medico-legal experts, and ethicists.  


Assessment, monitoring, or management and brain-dead Brain dead Brain death Brain-dead potential organ donor Inflammatory response and brain death Innate immunity and injury and brain death Multi-organ Neurocritical Organ donation Storage of thoracic organs Transplantation

Editors and affiliations

  • Dimitri Novitzky
    • 1
  • David K C Cooper
    • 2
  1. 1.Tampa VA Medical Center, SurgeryUniversity of South FloridaTampaUSA
  2. 2.Thomas E. Starzl Transplantation Institu, Department of SurgeryUniversity of Pittsburgh Medical CenterPittsburghUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine
  • Print ISBN 978-1-4614-4303-2
  • Online ISBN 978-1-4614-4304-9
  • Buy this book on publisher's site