Mechanisms and Emerging Therapies in Tremor Disorders

  • Giuliana Grimaldi
  • Mario Manto

Part of the Contemporary Clinical Neuroscience book series (CCNE)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Fundamental Aspects

    1. Front Matter
      Pages 1-1
    2. Giuliana Grimaldi, Mario Manto
      Pages 3-10
    3. Aasef G. Shaikh, Lance M. Optican, David S. Zee
      Pages 11-35
    4. Hideto Miwa
      Pages 37-51
    5. Fabio Coppedè
      Pages 53-78
    6. Dingguo Zhang, Wei Tech Ang
      Pages 79-107
  3. The Various Forms of Tremor in Clinical Practice: Presentation and Mechanisms

    1. Front Matter
      Pages 109-109
    2. Rodger J. Elble
      Pages 111-119
    3. Giuliana Grimaldi, Mario Manto
      Pages 121-131
    4. Jean-François Daneault, Benoit Carignan, Fariborz Rahimi, Abbas F. Sadikot, Christian Duval
      Pages 133-150
    5. Dennis A. Nowak, Hans-Jürgen Gdynia, Jan Raethjen
      Pages 151-166
    6. Stefania Lalli, Alberto Albanese
      Pages 203-218
    7. Julián Benito-León, Andrés Labiano-Fontcuberta, Elan D. Louis
      Pages 219-233
    8. Katherine A. Kendall
      Pages 235-248
    9. Eloi Magnin, Pierre Labauge, Lucien Rumbach, Marie Vidailhet
      Pages 249-262
    10. Jose Fidel Baizabal-Carvallo, Joseph Jankovic
      Pages 263-287
    11. Luis Redondo-Vergé, Natividad Carrion-Mellado
      Pages 289-304
    12. Padraic J. Grattan-Smith, Russell C. Dale
      Pages 305-322
  4. Assessment of Tremor: Clinical, Neurophysiological and Neuroimaging Aspects

    1. Front Matter
      Pages 323-323
    2. Giuliana Grimaldi, Mario Manto
      Pages 325-340
    3. James McNames
      Pages 371-389
    4. Johannes C. Klein
      Pages 391-401
    5. Michael Pourfar, Martin Niethammer, David Eidelberg
      Pages 403-415
  5. Therapies of Tremor

    1. Front Matter
      Pages 417-417
    2. Giuliana Grimaldi, Mario Manto
      Pages 419-429
    3. Julie J. Berk, Olga S. Klepitskaya
      Pages 431-443
    4. Ioannis U. Isaias, Jens Volkmann
      Pages 445-461
    5. Quincy J. Almeida, Fariborz Rahimi, David Wang, Farrokh Janabi-Sharifi
      Pages 463-475
  6. Back Matter
    Pages 477-492

About this book


Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex up to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness and damping are all factors influencing features of tremor. This book discusses the pathophysiology of tremor including membrane mechanisms and rodent models, the advances in genetics and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment, and provides practical informations for the daily management. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced. Future challenges are also presented.

Editors and affiliations

  • Giuliana Grimaldi
    • 1
  • Mario Manto
    • 2
  1. 1., Unité d'Etude due Mouvement (UEM)Neurologie ULB ErasmeBruxellesBelgium
  2. 2.BruxellesBelgium

Bibliographic information