Systems Biology of Apoptosis

  • Inna N. Lavrik

Table of contents

  1. Front Matter
    Pages i-xii
  2. Stefan Kallenberger, Stefan Legewie
    Pages 1-32
  3. Kolja Schleich, Inna N. Lavrik
    Pages 33-56
  4. Dennis Rickert, Nicolai Fricker, Inna N. Lavrik, Fabian J. Theis
    Pages 57-84
  5. Jochen H. M. Prehn, Heinrich J. Huber, Carla O’Connor
    Pages 85-99
  6. Rebekka Schlatter, Kathrin Schmich, Christoph Borner, Michael Ederer, Irmgard Merfort
    Pages 101-123
  7. Laurence Calzone, Andrei Zinovyev, Boris Zhivotovsky
    Pages 125-143
  8. Nicolai Fricker, Inna N. Lavrik
    Pages 145-161
  9. Christopher D. Deppmann, Kevin A. Janes
    Pages 163-180
  10. Christina Falschlehner, Michael Boutros
    Pages 181-197
  11. Back Matter
    Pages 199-203

About this book


Apoptosis is highly defined programmed cell death, which leads to the elimination of cells. Deregulation of programmed cell death is associated with serious diseases such as cancer, autoimmunity, AIDS and neurodegeneration. In recent years, apoptosis has been successfully studied using a systems biology approach. Systems biology is a novel field of science which combines mathematical modeling with experimental data leading to predictions of biological processes. The development of this field in recent years is fascinating. Studies of apoptosis using systems biology have provided novel insights into the quantitative regulation of cell death.

In Systems Biology of Apoptosis, contemporary systems biology studies devoted to cell death signaling both from experimental and modeling sides is discussed, as well as a focus on how systems biology helps to understand life/death decisions made in the cell and the development of new approaches to rational treatment strategies.

Editors and affiliations

  • Inna N. Lavrik
    • 1
  1. 1.Otto von Guericke University, Department of Translational InflammationInstitute of Experimental Internal MedicMagdeburgGermany

Bibliographic information