Mitochondrial Oxidative Phosphorylation

Nuclear-Encoded Genes, Enzyme Regulation, and Pathophysiology

  • Bernhard Kadenbach

Part of the Advances in Experimental Medicine and Biology book series (volume 748)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Andrew Ferree, Orian Shirihai
    Pages 13-40
  3. Johannes M. Herrmann, Sebastian Longen, Daniel Weckbecker, Matthieu Depuydt
    Pages 41-64
  4. Denis Pierron, Derek E. Wildman, Maik Hüttemann, Thierry Letellier, Lawrence I. Grossman
    Pages 185-213
  5. Shinya Yoshikawa, Kazumasa Muramoto, Kyoko Shinzawa-Itoh
    Pages 215-236
  6. Maik Hüttemann, Icksoo Lee, Lawrence I. Grossman, Jeffrey W. Doan, Thomas H. Sanderson
    Pages 237-264
  7. Rabia Ramzan, Petra Weber, Bernhard Kadenbach, Sebastian Vogt
    Pages 265-281
  8. Salvatore DiMauro, Kurenai Tanji, Eric A. Schon
    Pages 341-357
  9. Back Matter
    Pages 359-372

About this book


This book will describe the nuclear encoded genes and their expressed proteins of mitochondrial oxidative phosphorylation. Most of these genes occur in eukaryotic cells, but not in bacteria or archaea. The main function of mitochondria, the synthesis of ATP, is performed at subunits of proton pumps (complexes I, III, IV and V), which are encoded on mitochondrial DNA. The nuclear encoded subunits have mostly a regulatory function. However, the specific physiological functions of the nuclear encoded subunits of complexes I, III, IV, and V are mostly unknown. New data indicates that they are essential for life of higher organisms, which is characterized by an adult life without cell division (postmeiotic stage) in most tissues, after the juvenile growth. For complex IV (cytochrome c oxidase) some of these subunits occur in tissue-specific (subunits IV, VIa, VIb, VIIa, VIII), developmental-specific (subunits IV, VIa, and VIIa) as well as species-specific isoforms. Defective genes of some subunits were shown to induce mitochondrial diseases. Mitochondrial genes and human diseases will also be covered.

Editors and affiliations

  • Bernhard Kadenbach
    • 1
  1. 1.Philipps-Universitaet MarburgMarburgGermany

Bibliographic information