Principles of Research Methodology

A Guide for Clinical Investigators

  • Phyllis G. Supino
  • Jeffrey S. Borer

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Phyllis G. Supino
    Pages 1-14
  3. Phyllis G. Supino, Helen Ann Brown Epstein
    Pages 15-30
  4. Phyllis G. Supino
    Pages 31-53
  5. Peter L. Flom, Phyllis G. Supino, N. Philip Ross
    Pages 147-175
  6. Todd A. Durham, Gary G. Koch, Lisa M. LaVange
    Pages 207-231
  7. Eli A. Friedman
    Pages 233-254
  8. Jeffrey S. Borer
    Pages 255-268
  9. Back Matter
    Pages 269-276

About this book


Principles of Research Methodology: A Guide for Clinical Investigators is the definitive, comprehensive guide to understanding and performing clinical research. Designed for medical students, physicians, basic scientists involved in translational research, and other health professionals, this indispensable reference also addresses the unique challenges and demands of clinical research and offers clear guidance in becoming a more successful member of a medical research team and critical reader of the medical research literature. The book covers the entire research process, beginning with the conception of the research problem to publication of findings. Principles of Research Methodology: A Guide for Clinical Investigators comprehensively and concisely presents concepts in a manner that is relevant and engaging to read. The text combines theory and practical application to familiarize the reader with the logic of research design and hypothesis construction, the importance of research planning, the ethical basis of human subjects research, the basics of writing a clinical research protocol and scientific paper, the logic and techniques of data generation and management, and the fundamentals and implications of various sampling techniques and alternative statistical methodologies. Organized in thirteen easy to read chapters, the text emphasizes the importance of clearly-defined research questions and well-constructed hypothesis (reinforced throughout the various chapters) for informing methods and in guiding data interpretation. Written by prominent medical scientists and methodologists who have extensive personal experience in biomedical investigation and in teaching key aspects of research methodology to medical students, physicians and other health professionals, the authors expertly integrate theory with examples and employ language that is clear and useful for a general medical audience. A major contribution to the methodology literature, Principles of Research Methodology: A Guide for Clinical Investigators is an authoritative resource for all individuals who perform research, plan to perform it, or wish to understand it better.

Editors and affiliations

  • Phyllis G. Supino
    • 1
  • Jeffrey S. Borer
    • 2
  1. 1., Cardiovascular MedicineSUNY Downstate Medical CenterBrooklynUSA
  2. 2., Cardiovascualr MedicineSUNY Downstate Medical CenterBrooklynUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2012
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-1-4614-3359-0
  • Online ISBN 978-1-4614-3360-6
  • Buy this book on publisher's site