Renal Cell Carcinoma

Translational Biology, Personalized Medicine, and Novel Therapeutic Targets

  • Robert A. Figlin
  • W. Kimryn Rathmell
  • Brian I. Rini

Table of contents

  1. Front Matter
    Pages i-xi
  2. Biology of Renal Cell Carcinoma

    1. Front Matter
      Pages 1-1
    2. Laura S. Schmidt, Ramaprasad Srinivasan, W. Marston Linehan
      Pages 3-25
    3. William G. Kaelin Jr.
      Pages 27-47
    4. Bin Tean Teh, Leslie J. Farber, Kyle Furge
      Pages 91-111
  3. Current and Future Molecular Targets for RCC

    1. Front Matter
      Pages 113-113
    2. Cristina Suarez, Brian I. Rini
      Pages 115-133
    3. James Brugarolas
      Pages 161-191
    4. Swathi Ramakrishnan, Roberto Pili
      Pages 193-211
    5. Hema Vankayala, Patricia LoRusso, Ulka Vaishampayan
      Pages 213-238
    6. Sumanta Kumar Pal, Karen Reckamp, Hua Yu, Robert A. Figlin, Robert A. Figlin, Robert A. Figlin
      Pages 239-252
    7. Hyung L. Kim, Edwin M. Posadas, Robert A. Figlin, Robert A. Figlin, Robert A. Figlin
      Pages 271-282
  4. Back Matter
    Pages 323-327

About this book

Introduction

This volume examines every major topic area in the modern era of renal carcinoma biology and treatment.   The unique and intricate genetics of this cancer are highly distinct from most other tumors, and the advances made in this cancer beyond VHL biology have been intrinsically driven by discoveries from familial renal cell carcinomas linked with newer large scale genomic efforts in sporadic disease.  These genetic findings fuel strategies to analyze and define sporadic tumors for greater accuracy in prognosis and prediction of response to therapy.  

Additional topics include major new therapeutic strategies that harness these biological discoveries, in particular angiogenic, energy metabolism, chromatin remodeling, tumor microenvironment, and classical signaling pathways.   This text will bring all of these avenues of investigation together for readers interested in understanding the dynamics of this field in the last decade and anticipating a continued steep trajectory in advancements toward the cure of this disease in its many manifestations.

Keywords

Carcinoma Renal Renal Cell prognostic therapeutic

Editors and affiliations

  • Robert A. Figlin
    • 1
  • W. Kimryn Rathmell
    • 2
  • Brian I. Rini
    • 3
  1. 1.David Geffen School of Medicine at UCLA, Department of MedicineCedars-Sinai Medical CenterLos AngelesUSA
  2. 2.Lineberger Comprehensive Cancer CenterUniversity of North CarolinaChapel HillUSA
  3. 3.Taussig Cancer Institute, Department of Solid Tumor OncologyCleveland ClinicCLEVELANDUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-2400-0
  • Copyright Information Springer Science+Business Media, LLC 2012
  • Publisher Name Springer, Boston, MA
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-2399-7
  • Online ISBN 978-1-4614-2400-0
  • About this book