Myelin Repair and Neuroprotection in Multiple Sclerosis

  • Ian D. Duncan
  • Robin J M Franklin

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Lars Bø, Margaret Esiri, Nikos Evangelou, Tanja Kuhlmann
    Pages 23-45
  3. Trevor J. Kilpatrick, Vilija G. Jokubaitis
    Pages 47-70
  4. Robin J. M. Franklin, Chao Zhao, Catherine Lubetzki, Charles ffrench-Constant
    Pages 71-92
  5. V. Zujovic, A. Baron Van Evercooren
    Pages 129-152
  6. Tamir Ben-Hur, Stefano Pluchino, Gianvito Martino
    Pages 153-178
  7. Joel A. Black, Kenneth J. Smith, Stephen G. Waxman
    Pages 179-201
  8. Douglas L. Arnold, Catherine M. Dalton, Klaus Schmierer, G. Bruce Pike, David H. Miller
    Pages 233-253
  9. P. Connick, M. Kolappan, A. Compston, S. Chandran
    Pages 255-276
  10. Back Matter
    Pages 277-287

About this book

Introduction

Myelin Repair and Neuroprotection in Multiple Sclerosis presents an up-date on the translational potential of promoting remyelination in multiple sclerosis (MS).  A number of research frontiers still exist in this challenging disease.  The cause remains elusive, preventing breakthroughs in its prevention.  The move towards oral immunomodulatory therapies has been a major advance, as has the finding of new genes linked to susceptibility that may open the door to new therapeutic approaches.  However, a frontier that has been making significant strides in recent years has been that surrounding the neurobiology of myelin regeneration and axon protection: such have been the advances that clinical translation is on the cusp of being achieved. Two broad approaches to therapeutic enhancement of remyelination are envisaged: promoting endogenous remyelination by targeting cells present in the CNS, or, replacing lost myelinating cells from exogenous sources.  Current research on oligodendrocyte biology, the pathology of MS, imaging of lesions and the biology of remyelination are paving the way toward opening this new translational frontier.

 

Professor Duncan and Professor Franklin have assembled a broad group of experts in the fields of glial cell biology, neuropathology, radiology and clinical neurology to provide the background toward taking remyelination from experimented models into MS patients. 

Editors and affiliations

  • Ian D. Duncan
    • 1
  • Robin J M Franklin
    • 2
  1. 1.School Veterinary Medicine, Dept. Medical SciencesUniversity of Wisconsin MadisonMadisonUSA
  2. 2.Wellcome Trust and MRC Cambridge Stem Ce, and Department of Veterinary MedicineUniversity CambridgeCambridgeUnited Kingdom

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-2218-1
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Springer, Boston, MA
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-2217-4
  • Online ISBN 978-1-4614-2218-1
  • About this book