© 2012

Signaling at the Cell Surface in the Circulatory and Ventilatory Systems


Table of contents

  1. Front Matter
    Pages i-xv
  2. Marc Thiriet
    Pages 1-9
  3. Marc Thiriet
    Pages 11-88
  4. Marc Thiriet
    Pages 89-156
  5. Marc Thiriet
    Pages 157-271
  6. Marc Thiriet
    Pages 273-333
  7. Marc Thiriet
    Pages 335-359
  8. Marc Thiriet
    Pages 361-424
  9. Marc Thiriet
    Pages 425-591
  10. Marc Thiriet
    Pages 593-687
  11. Marc Thiriet
    Pages 689-703
  12. Marc Thiriet
    Pages 705-755
  13. Marc Thiriet
    Pages 757-808
  14. Back Matter
    Pages 809-982

About this book


The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning.

Volume 3 is devoted to the set of mediators of the cell surface, especially ion and molecular carriers and catalytic receptors that, once liganded and activated, initiate signal transduction pathways. Intracellular cascades of chemical reactions trigger the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Primary mediators are included in models of regulated cellular processes, but multiple secondary signaling components are discarded to allow simple, representative modeling and to manage their inverse problems.

Reviews signaling pathways in the regulation of circulatory and respiratory function

Describes ion and molecular carriers and receptors

Integrates biology, chemistry, and physics for a multidisciplinary understanding of physiological flows


blood flow behavior blood flow prediction cardiovascular systems modeling cell signalling pathways ion and molecule carriers described modeling respiratory function modeling simulation of flows physiological flows receptors ligands signaling mediators explained ventilatory systems modeling

Authors and affiliations

  1. 1.Laboratoire Jacques-Louis Lions, Institut Universitaire de FranceUniversité Pierre et Marie CurieParisFrance

Bibliographic information